Evidence map›Paper›PMID 36576223›Full record

ArticleHuman vaccines & immunotherapeutics2022

Evaluation of immunogenicity post two doses of inactivated SARS-CoV-2 vaccine, Covaxin after six months.

Rima R Sahay, Pragya D Yadav, Ashok Nandapurkar, Rutuja Dhawde, Annasaheb Suryawanshi, Deepak Y Patil, Anita M Shete, Gajanan N Sapkal, Milind Kulkarni, Yogesh K Gurav and 8 more

Abstract readLetter
In one paragraph

Article in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rima R SahayMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Pragya D YadavMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Ashok NandapurkarAundh Chest Hospital, Pimpri-Chinchwad, Pune, India.
Rutuja DhawdeMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Annasaheb SuryawanshiMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Deepak Y PatilMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Anita M SheteMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Gajanan N SapkalMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Milind KulkarniAundh Chest Hospital, Pimpri-Chinchwad, Pune, India.
Yogesh K GuravMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Gururaj R DeshpandeMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Jagdevi S GhodkeAundh Chest Hospital, Pimpri-Chinchwad, Pune, India.
Rajlaxmi JainMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Raj HawaleMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Kaumudi KaleleMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Jyoti YemulMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Pranita GawandeMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.
Priya AbrahamMaximum Containment Facility, Indian Council of Medical Research-National Institute of Virology, Pune, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have evaluated the immunogenicity of two dose of Covaxin given at a one-month interval to two adult populations, i.e. COVID-19 naïve-vaccinated individuals (n = 118) and COVID-19 recovered individuals (n = 128) with the vaccination. The immune response in the study population were assessed at three follow-ups, namely at one month post first dose, one and six months after the second dose. The persistence of S1RBD IgG and neutralizing antibodies for six months post vaccination was observed at different time intervals. The enhanced immune response was observed in both the participant groups. The study emphasizes the need for a booster dose post six months of vaccination.

Indexed as

COVID-19COVID-19 VaccinesAdultAntibodies, NeutralizingAntibodies, ViralHumansImmunogenicity, VaccineSARS-CoV-2Vaccines, InactivatedAntibodies, NeutralizingAntibodies, ViralBBV152 COVID-19 vaccineCOVID-19 VaccinesVaccines, Inactivatedadult populationCovaxinimmunogenicitySars-CoV-2

Identifiers

PMID36576223
PMCPMC9891675

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.