Evidence map›Paper›PMID 36575700›Full record

ArticleSouthern African journal of HIV medicine2022

COVID-19 and HIV viral load suppression in children and adolescents in Durban, South Africa.

Asandile Mathamo, Kimesh L Naidoo, Jienchi Dorward, Thashir Archary, Christian Bottomley, Moherndran Archary

Open access · goldAbstract read
In one paragraph

Article in Southern African journal of HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Diagnoses of children living with HIV before and during the COVID-19 pandemic.Southern African journal of infectious diseases · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Asandile MathamoDepartment of Paediatrics and Child Health, Faculty of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.ORCID https://orcid.org/0000-0001-5683-2162
Kimesh L NaidooDepartment of Paediatrics and Child Health, Faculty of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.ORCID https://orcid.org/0000-0003-4940-0534
Jienchi DorwardNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-6072-1430
Thashir ArcharyDepartment of Engineering, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0003-2022-5189
Christian BottomleyLondon School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID https://orcid.org/0000-0002-5241-8412
Moherndran ArcharyNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0003-3082-9234
University of KwaZulu-Natal · ZACentre for the AIDS Programme of Research in South Africa · ZAKing Edward VIII Hospital · ZALondon School of Hygiene & Tropical Medicine · GBUniversity of the Witwatersrand · ZA

Funding

Medical Research Council MR/R010161/1
6 · The paper itself

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic poses challenges to paediatric and adolescent HIV treatment programme. Modelling exercises raised concerns over potential impact of disruptions. Objectives: To describe the impact of the COVID-19 pandemic on viral load (VL) testing among infants, children and adolescents on antiretroviral treatment (ART) in Durban, South Africa. Method: Routinely collected, aggregated data of monthly VL counts done on all those less than 19 years old from January 2018 to January 2022 was analysed. An interrupted time series analysis using a Prais-Winsten linear regression model, including terms for lockdowns and excess mortality determined VL trends. Results: The unadjusted mean VL was 2166 (confidence interval [CI]: 252.2) and 2016 (CI: 241.9), Conclusion: Viral load suppression for children and adolescents were not negatively affected by COVID-19. A trend of decrease in VL testing predated COVID-19. What this study adds: Evidence presented that HIV VL testing and suppression rates in children and adolescents in a high burden setting were sustained through the COVID pandemic.

Indexed as

childrenCOVID-19paediatric HIVSouth Africaviral load testing

Identifiers

PMID36575700
PMCPMC9772656
OpenAlexW4308248856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.