ArticleMicrosystems & nanoengineering2022
A flexible neural implant with ultrathin substrate for low-invasive brain-computer interface applications.
Article in Microsystems & nanoengineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 54 citations in OpenAlex.
- Nanomaterial -enabled flexible sensors for continuous biomedical monitoring and closed-loop intervention.Discover nano · 2026Review
- A comparative study assessing neural recording quality and inflammatory tissue response between stiff and flexible microelectrode arrays.Biomaterials · 2026Article
- Advances in neuroprostheses: interfaces, materials, and applications.Nano convergence · 2026Review
- An Ultra-Flexible Neural Electrode with Bioelectromechanical Compatibility and Brain Micromotion Detection.Advanced healthcare materials · 2026Article
- Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex.Advanced healthcare materials · 2026Article
- Autonomous Implants.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Cell-to-cell communication: from physical calling to remote emotional touching.Discover nano · 2025Article
- Bidirectional mechanisms and emerging strategies for implantable bioelectronic interfaces.Bioactive materials · 2025Review
- Stiffness-Tunable Neurotentacles for Minimally Invasive Implantation and Long-Term Neural Activity Recordings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats.Nature communications · 2025Article
- Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording.Microsystems & nanoengineering · 2025Article
- Enhancing biocompatibility of the brain-machine interface: A review.Bioactive materials · 2024Review
- Ultraflexible PEDOT:PSS/IrOMicromachines · 2024Article
- Editorial: Problems, strategies, and developments for high-density long-term chronic intracortical neural interfaces and their application.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantable brain-computer interface (BCI) devices are an effective tool to decipher fundamental brain mechanisms and treat neural diseases. However, traditional neural implants with rigid or bulky cross-sections cause trauma and decrease the quality of the neuronal signal. Here, we propose a MEMS-fabricated flexible interface device for BCI applications. The microdevice with a thin film substrate can be readily reduced to submicron scale for low-invasive implantation. An elaborate silicon shuttle with an improved structure is designed to reliably implant the flexible device into brain tissue. The flexible substrate is temporarily bonded to the silicon shuttle by polyethylene glycol. On the flexible substrate, eight electrodes with different diameters are distributed evenly for local field potential and neural spike recording, both of which are modified by Pt-black to enhance the charge storage capacity and reduce the impedance. The mechanical and electrochemical characteristics of this interface were investigated in vitro. In vivo, the small cross-section of the device promises reduced trauma, and the neuronal signals can still be recorded one month after implantation, demonstrating the promise of this kind of flexible BCI device as a low-invasive tool for brain-computer communication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.