Evidence map›Paper›PMID 36575538›Full record

SynthesisEuropean journal of medical research2022

Breast cancer risk factors in Iranian women: a systematic review and meta-analysis of matched case-control studies.

Malihe Khoramdad, Masoud Solaymani-Dodaran, Ali Kabir, Neda Ghahremanzadeh, Esmat-O-Sadat Hashemi, Noushin Fahimfar, Zahra Omidi, Mohammad Ali Mansournia, Asiie Olfatbakh, Hamid Salehiniya and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in European journal of medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  9. Association of lifestyle factors with breast cancer incidence: An overview of systematic reviews.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
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  11. Risk Factors Associated with Breast Cancer among Women in Iraq: A Case-Control Study.Asian Pacific journal of cancer prevention : APJCP · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Malihe KhoramdadDepartment of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Masoud Solaymani-DodaranDepartment of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. msdodran@gmail.com.
Ali KabirMinimally Invasive Surgery Research Center, Hazrat-E-Rasool Hospital, Iran University of Medical Science, Tehran, Iran.
Neda GhahremanzadehDepartment of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Esmat-O-Sadat HashemiBreast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Noushin FahimfarOsteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Zahra OmidiBreast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Mohammad Ali MansourniaDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Asiie OlfatbakhBreast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Hamid SalehiniyaSocial Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Shahpar HaghighatBreast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran. haghighat@acecr.ac.ir.
Academic Center for Education, Culture and Research · IRIran University of Medical Sciences · IRTehran University of Medical Sciences · IRBirjand University of Medical Sciences · IRRasool Akram Hospital · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentifying breast cancer risk factors is a critical component of preventative strategies for this disease. This study aims to identify modifiable and non-modifiable risk factors of breast cancer in Iranian women.

methodsWe used international databases (PubMed/Medline, Scopus, Web of Knowledge, and Embase) and national databases (SID, Magiran, and ISC) to retrieve relevant studies until November 13, 2022. The odds ratio (OR) with a 95% confidence interval using the random-effect model was used to estimate the pooled effect. The publication bias was assessed by the Egger and Begg test. A sensitivity analysis was conducted to evaluate the effect of each included study on the final measurement.

resultsOf the 30,351 retrieved articles, 24 matched case-control records were included with 12,460 participants (5675 newly diagnosed cases of breast cancer and 6785 control). This meta-analysis showed that of the known modifiable risk factors for breast cancer, obesity (vs normal weight) had the highest risk (OR = 2.17, 95% CI 1.47 to 3.21; I

conclusionsSince most risk factors related to breast cancer incidence are modifiable, promoting healthy lifestyles can play an influential role in preventing breast cancer. In women with younger menarche age, a family history of breast cancer, or a history of radiation exposure, screening at short intervals is recommended.

Indexed as

Breast NeoplasmsAdolescentCase-Control StudiesFemaleHumansIranObesityPregnancyRisk FactorsBreast neoplasmsCase–control studiesMeta-analysisRisk factors

Identifiers

PMID36575538
PMCPMC9793603
OpenAlexW4312200219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.