SynthesisGenome biology2022
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Genome biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
10.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Identifying the risk factors of autism spectrum disorders in infants born preterm: a systematic review and meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Shared genetic underpinnings of gray matter volume alterations and metabolic traits in major depressive disorder.BMC psychiatry · 2026Pooled it
- Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.Nature genetics · 2026Pooled it
- Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis.Biology of sex differences · 2024Pooled it
- Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.Genome biology · 2022Pooled it
- Experimental pasta as an innovative approach to cholesterol reduction in patients with metabolic syndrome, with and without major psychiatric disorders: A randomized controlled trial supported byEuropean psychiatry : the journal of the Association of European Psychiatrists · 2025Trial
- Association between saturated fat intake and low-density lipoprotein cholesterol across the genetic spectrum: Results from the Women's Health Initiative.medRxiv : the preprint server for health sciences · 2026Article
- From GWAS Signals to Molecular Mechanisms: Explainable AI for Causal Gene Prioritization and Biomolecular Target Interpretation.Biomolecules · 2026Review
- PCSK9 and Breast Cancer Survival: A Mendelian Randomization Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations.Nature genetics · 2026Article
- Genetic array data from the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA).Research square · 2026Article
- Multi-ancestry transcriptome prediction with functionally informed variants in TOPMed MESA improves performance of transcriptome-wide association studies.American journal of human genetics · 2026Article
- Higher Circulating Testosterone Linked to Higher CAD Risk in Men: Mendelian Randomization and Survival Analyses.The Journal of clinical endocrinology and metabolism · 2026Article
- Lipid-lowering and glucose-lowering drug targets differentially modulate antipsychotic treatment efficacy in schizophrenia.Cell reports. Medicine · 2026Article
- Pharmacogenomic predictors of drug response and choice in dyslipidemia and hypertension.medRxiv : the preprint server for health sciences · 2026Article
- Offspring BMI and lipid profiles following assisted reproductive technology: a comparative study of underweight and normal-weight mothers.Lipids in health and disease · 2026Article
- Mendelian Randomization With Longitudinal Exposure Data: Simulation Study and Real Data Application.Statistics in medicine · 2026Article
- The Roles of EDA2R in Ageing and Disease.Aging cell · 2025Review
- Assessing long-term pleiotropic effects of potential novel triglyceride-lowering medications using variants identified by Mendelian randomization.medRxiv : the preprint server for health sciences · 2025Article
- Methods for multiancestry genome-wide association study meta-analysis.Annals of human genetics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
539 authors at 20 institutions in 36 countries.
Stavroula Kanoni *William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Sarah E Graham *Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Yuxuan Wang *Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA.
Ida Surakka *Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Shweta Ramdas *Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Xiang Zhu *Department of Statistics, The Pennsylvania State University, University Park, PA, USA.
Shoa L ClarkeVA Palo Alto Health Care Systems, Palo Alto, CA, USA.
Konain Fatima BhattiWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Sailaja VedantamBoston Children's Hospital, EndocrinologyBoston, MA, 02115, USA.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Adam E LockeMcDonnell Genome Institute and Department of Medicine, Washington University, St. Louis, MO, 63108, USA.
Eirini MarouliWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Greg J M ZajacDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Kuan-Han H WuDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Ioanna NtallaClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Qin HuiDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Derek KlarinVA Palo Alto Health Care Systems, Palo Alto, CA, USA.
Austin T HilliardVA Palo Alto Health Care Systems, Palo Alto, CA, USA.
Zeyuan WangDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Chao XueDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Gudmar ThorleifssondeCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.
Anna HelgadottirdeCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.
Daniel F GudbjartssondeCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.
Hilma HolmdeCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.
Isleifur OlafssonDepartment of Clinical Biochemistry, Landspitali - National University Hospital of Iceland, Hringbraut, Reykjavik, 101, Iceland.
Mi Yeong HwangDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Sohee HanDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Masato AkiyamaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Saori SakaueLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Masahiro KanaiProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Wei ZhouProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Ben M BrumptonK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Humaira RasheedK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Aki S HavulinnaInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Yogasudha VeturiDepartment of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Jennifer Allen PachecoCenter for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60618, USA.
Elisabeth A RosenthalDepartment of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.
Todd LingrenDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
QiPing FengDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Iftikhar J KulloDepartment of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA.
Akira NaritaTohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Jun TakayamaTohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Hilary C MartinWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Karen A HuntBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Bhavi TrivediBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jeffrey HaesslerFred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA, 9810, USA.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Yuki BradfordDepartment of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Jason E MillerDepartment of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Kuang LinClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Iona Y MillwoodClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Asif RasheedCenter for Non-Communicable Diseases, Karachi, Sindh, Pakistan.
George HindyDepartment of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Wei ZhaoSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Constance TurmanProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
Hongyan HuangProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Ananyo ChoudhurySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Dhriti SenguptaSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Anubha MahajanWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Michael R BrownHuman Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Ketian YuDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Ellen M SchmidtDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Anita PanditDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Stefan GustafssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Xianyong YinDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Jing-Hua ZhaoCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hye-Mi JangDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Kyungheon YoonDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Carolina Medina-GomezDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Achilleas PitsillidesDepartment of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA.
Jouke Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Yingji JiGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Zishan GaoNanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.
Simon HaworthMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
Noha A YousriDepartment of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.
Ruth E MitchellMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
Jin Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Mette AadahlCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Anne A BjerregaardCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA.
Chii-Min HwuSection of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yi-Jen HungInstitute of Preventive Medicine, National Defense Medical Center, Postbox 90048~700, Sanhsia Dist, New Taipei City, 237101, Taiwan.
Helen R WarrenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
Julia RamirezWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
Jette Bork-JensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Line L KårhusCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Anuj GoelWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Maria Sabater-LlealUnit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Pala MauroIstituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy.
Floris MatteoIstituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy.
Aaron F McDaidUniversity Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010, Lausanne, Switzerland.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Matthias WielscherDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Naveed SattarBHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK.
Line T MøllehaveCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Matthias MunzInstitute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck and Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany.
Lingyao ZengDeutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München, Munich, Germany.
Jianfeng HuangKey Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Bin YangKey Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Alaitz PovedaLund University Diabetes Center, Lund University, Malmö, Sweden.
Azra KurbasicLund University Diabetes Center, Lund University, Malmö, Sweden.
Claudia LaminaInstitute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Lukas ForerInstitute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.
Tessel E GaleslootRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Jonathan P BradfieldQuantinuum Research LLC, Wayne, PA, 19087, USA.
Sanni E RuotsalainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
EWarwick DawDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Joseph M ZmudaDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Jonathan S MitchellInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy.
Christian FuchsbergerInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy.
Henry ChristensenDepartment of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA.
Miguel Vazquez-MorenoUnidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Mary K WojczynskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Zhe WangThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael H PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
Paraskevi ChristofidouDepartment of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jan W BenjaminsDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jorgen EngmannInstitute of Cardiovascular Sciences, University College London, Gower Street, London, WC1E 6BT, UK.
Noah L TsaoDepartment of Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Anurag VermaDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Roderick C SliekerAmsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.
Ken Sin LoMontreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada.
Nuno R ZilhaoIcelandic Heart Association, 201, Kopavogur, Iceland.
Phuong LeDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
Shaofeng HuoShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Daisuke D IkedaBiomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan.
Hiroyuki IhaBiomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan.
Jian YangSchool of Life Sciences, Westlake University, Hangzhou, 310024, Zhejiang, China.
Jun LiuNuffield Department of Population Health, University of Oxford, Oxford, UK.
Ayşe DemirkanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Hampton L LeonardLaboratory of Neurogenetics, National Institute On Aging, NIH, Bethesda, MD, USA.
Jonathan MartenMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.
Mirjam FrankInstitute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.
Börge SchmidtInstitute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.
Laura J SmythCentre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.
Marisa Cañadas-GarreCentre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.
Chaolong WangDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Masahiro NakatochiPublic Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK.
Nina Hutri-KähönenTampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Rui XiaBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Alicia Huerta-ChagoyaCONACYT, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Ciudad de Mexico, Mexico.
Juan Carlos Fernandez-LopezDepartamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Valeriya LyssenkoLund University Diabetes Center, Lund University, Malmö, Sweden.
Suraj S NongmaithemAcademy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Swati BayyanaGenomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India.
Heather M StringhamDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Marguerite R IrvinEpidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Christopher OldmeadowHunter Medical Research Institute, Newcastle, Australia.
Han-Na KimMedical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, Korea.
Seungho RyuCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 04514, Korea.
Paul R H J TimmersMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.
Liubov ArbeevaThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Leslie A LangeDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO, 80045, USA.
Gauri PrasadGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110020, India.
Laura Lorés-MottaDepartments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands.
Marc PauperDepartments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands.
Jirong LongVanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA.
Xiaohui LiThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Elizabeth TheuschDepartment of Pediatrics, University of California San Francisco, Oakland, CA, 94609, USA.
Fumihiko TakeuchiNational Center for Global Health and Medicine, Tokyo, 1628655, Japan.
Cassandra N SpracklenDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Anu LoukolaInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Sailalitha BollepalliInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Sophie C WarnerDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Ya Xing WangBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China.
Wen B WeiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, Dong Cheng District, China.
Teresa NutileInstitute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy.
Daniela RuggieroInstitute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy.
Yun Ju SungDivision of Biostatistics, Washington University, St. Louis, MO, 63110, USA.
Shufeng ChenKey Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Fangchao LiuKey Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Jingyun YangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Katherine A KentistouCentre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Bernhard BanasDept of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Giuseppe Giovanni NardoneInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Karina MeidtnerDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Prashantha HebbarDepartment of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
Aliki-Eleni FarmakiDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Maoxuan LinMassachusetts General Hospital Cancer Center, Charlestown, MA, 02129, USA.
Maria Pina ConcasInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Simona VaccargiuInstitute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands.
Niina PitkänenResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Brian E CadeSleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Sander W van der LaanCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Kumaraswamy Naidu ChitralaLaboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD, 20892-9205, USA.
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany.
Amy R BentleyCenter for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA.
Ayo P DoumateyCenter for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA.
Adebowale A AdeyemoCenter for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA.
Jong Young Lee, Oneomics. Co. Ltd. 2F, Soonchunhyang Mirai Medical Center 173, Buheuyng-Ro, Bucheon-Si Gyeonggi-Do, 14585, Korea.
Eva R B PetersenDepartment of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Kresten Philipsens Vej 15, 6200, Aabenraa, Denmark.
Aneta A NielsenDepartment of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark.
Hyeok Sun ChoiDepartment of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea.
Maria NethanderCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sandra Freitag-WolfInstitute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.
Lorraine SouthamWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Nigel W RaynerWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Carol A WangSchool of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia.
Shih-Yi LinCenter for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Jun-Sing WangDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Christian CoutureDepartment of Kinesiology, Université Laval, Québec, Canada.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland.
Kjell NikusDepartment of Cardiology, Heart Center, Tampere University Hospital, 33521, Tampere, Finland.
Gabriel Cuellar-PartidaUniversity of Queensland Diamantina Institute, Translational Research Institute, Kent St, Woolloongabba, Brisbane, QLD, 4102, Australia.
Henrik VestergaardNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bertha HidalgoDepartment of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Olga GiannakopoulouWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Qiuyin CaiVanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA.
Morgan O OburaAmsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.
Jessica van SettenCardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Xiaoyin LiDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Jingjing LiangDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Hua TangDepartment of Genetics, Stanford University School of Medicine Stanford, Palo Alto, CA, 94305, USA.
Natalie TerzikhanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Jae Hun ShinDepartment of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea.
Rebecca D JacksonDivision of Endocrinology, Ohio State University, Columbus, OH, 43210, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, 98195, USA.
Lisa Warsinger MartinSchool of Medicine and Health Sciences, George Washington University, Washington, DC, 20037, USA.
Zhengming ChenClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Liming LiDepartment of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China.
Takahisa KawaguchiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Joachim ThieryInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD, 20892-9205, USA.
Huaixing LiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Mike A NallsCenter for Alzheimer's and Related Dementias, NIH, Bethesda, MD, USA.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Sahoko IchiharaDepartment of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498, Japan.
Sarah H WildCentre for Population Health Sciences, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Harry CampbellCentre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Susanne JägerDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Toru NabikaDepartment of Functional Pathology, Shimane University School of Medicine, Izumo, 6938501, Japan.
Fahd Al-MullaDepartment of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
Harri NiinikoskiDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Peter S BraundDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Ivana KolcicUniversity of Split School of Medicine, Šoltanska 2, HR-21000, Split, Croatia.
Peter KovacsUniversity of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany.
Tota GiardoglouDepartment of Nutrition-Dietetics, Harokopio University, Eleftheriou Venizelou, 17676, Athens, Greece.
Tomohiro KatsuyaDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, 5650871, Japan.
Dominique de KleijnDepartment of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Gert J de BorstDepartment of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Eung Kweon KimCorneal Dystrophy Research Institute, Yonsei University College of Medicine, Saevit Eye Hospital, SeoulIlsan, 03722, Korea.
Hieab H H AdamsDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Folkert W AsselbergsCardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Adriaan O KraaijeveldCardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Joline W J BeulensAmsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.
Xiao-Ou ShuVanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA.
Loukianos S RallidisSecond Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Paul MitchellCenter for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Hawkesbury Rd, Sydney, NSW, 2145, Australia.
Alex W HewittSchool of Medicine, Menzies Institute for Medical Research, University of Tasmania, Liverpool St, Hobart, TAS, 7000, Australia.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, 33521, Tampere, Finland.
Louis PérusseDepartment of Kinesiology, Université Laval, Québec, Canada.
Claude BouchardPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Anke TönjesUniversity of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Craig E PennellSchool of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia.
Trevor A MoriDiscipline of Internal Medicine, Medical School, The University of Western Australia, Perth, WA, Australia.
Wolfgang LiebInstitute of Epidemiology, Kiel University, Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Dan MellströmCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Yoon Shin ChoDepartment of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea.
Hyejin LeeDepartment of Internal Medicine, EwhaWomans University School of Medicine, Seoul, Korea.
Jian-Min YuanDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15232, USA.
Woon-Puay KohHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.
Sang Youl RheeDepartment of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea.
Jeong-Taek WooDepartment of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea.
Iris M HeidDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Klaus J StarkDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Martina E ZimmermannDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany.
Michele K EvansLaboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Alan B ZondermanLaboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Ozren PolasekUniversity of Split School of Medicine, Šoltanska 2, HR-21000, Split, Croatia.
Gerard PasterkampCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Imo E HoeferCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Susan RedlineSleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Katja PahkalaResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands.
Ginevra BiinoInstitute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Helena SchmidtGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Stefania BandinelliLocal Health Unit Toscana Centro, Florence, Italy.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.
Thangavel Alphonse ThanarajDepartment of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Norihiro KatoNational Center for Global Health and Medicine, Tokyo, 1628655, Japan.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Giorgia GirottoInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Carsten A BögerDept of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Bettina JungDept of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Peter K JoshiCentre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Philip L De JagerProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Xiangfeng LuKey Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Vasiliki MamakouMedical School, National and Kapodistrian University Athens, 75 M. Assias Street, 115 27, Athens, Greece.
Morris BrownNIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Mark J CaulfieldWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Marina CiulloInstitute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy.
Jost B JonasBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Päivi PajukantaDepartment of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
Teresa Tusié-LunaUnidad de Biología Molecular Y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, Mexico.
Carlos A Aguilar-SalinasDepartamento de Endocrinología Y Metabolismo, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, 14080, Mexico, Mexico.
Linda S AdairDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.
Sonny Augustin BechaydaUSC-Office of Population Studies Foundation, University of San Carlos, 6000, Cebu City, Philippines.
H Janaka de SilvaDepartment of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka.
Ananda R WickremasingheDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka.
Ronald M KraussChildren's Hospital Oakland Research Institute, Oakland, CA, 94609, USA.
Jer-Yuarn WuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Wei ZhengVanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA.
Anneke Iden HollanderDepartments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands.
Dwaipayan BharadwajAcademy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Ghaziabad, Uttar Pradesh, India.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Amanda E NelsonThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.
Yvonne M GolightlyDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.
Brenda PenninxAmsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands.
Hyung-Lae KimDepartment of Biochemistry, College of Medicine, Ewha Womans University, Seoul, 07804, Korea.
John AttiaHunter Medical Research Institute, Newcastle, Australia.
Rodney J ScottHunter Medical Research Institute, Newcastle, Australia.
D C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, USA.
Donna K ArnettOffice of the Provost, University of South Carolina, Columbia, SC, USA.
Steven C HuntDepartment of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.
Mark WalkerInstitute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Heikki A KoistinenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Giriraj R ChandakAcademy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Josep M MercaderPrograms in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Maria C CostanzoPrograms in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Dongkeun JangPrograms in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Noël P BurttPrograms in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Clicerio Gonzalez VillalpandoInstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes, Cuernavaca, Mexico.
Lorena OrozcoLaboratorio de Inmunogenómica Y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
EShyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland.
Nish ChaturvediMRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK.
Mitsuhiro YokotaKurume University School of Medicine, Kurume, 830-0011, Japan.
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Dermot F ReillyGenetics, Merck Sharp & Dohme Corp., Kenilworth, NJ, 07033, USA.
Amy Jayne McKnightCentre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.
Frank KeeCentre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.
Mark I McCarthyWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Colin N A PalmerPopulation Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee, DD1 9SY, UK.
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.
Eleanor SimonsickIntramural Research Program, National Institute On Aging, 3001 S. Hanover St., Baltimore, MD, 21225, USA.
Cornelia M van DuijnNuffield Department of Population Health, University of Oxford, Oxford, UK.
Zi-Bing JinBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, 100730, China.
Jia QuThe Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Haretsugu HishigakiBiomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan.
Xu LinShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
Vilmundur GudnasonIcelandic Heart Association, 201, Kopavogur, Iceland.
Jean-Claude TardifMontreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada.
Guillaume LettreMontreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada.
Leen M 't HartDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.
Petra J M EldersDepartment of General Practice, Amsterdam UMC, Amsterdam, 1081HV, the Netherlands.
Scott M DamrauerDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Meena KumariInstitute of Social and Economic Research, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
Ruth J F LoosNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Esteban J ParraDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada.
Miguel CruzUnidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA.
Ivan BrandslundDepartment of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
Peter P PramstallerInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy.
Charles N RotimiCenter for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA.
Kaare ChristensenDanish Aging Research Center, University of Southern Denmark, Odense C, Denmark.
Samuli RipattiInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Elisabeth WidénInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Struan F A GrantDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Lambertus A L M KiemeneyRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Jacqueline de GraafRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.
Florian KronenbergInstitute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Dongfeng GuKey Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Jeanette ErdmannInstitute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, and University Heart Center Lübeck, Lübeck, Germany.
Heribert SchunkertDeutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München, Munich, Germany.
Paul W FranksLund University Diabetes Center, Lund University, Malmö, Sweden.
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Amit V KheraProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Minna MännikköNorthern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Zoltan KutalikUniversity Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010, Lausanne, Switzerland.
Cucca FrancescoInstitute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari, Italy.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Ko Willems van DijkDepartment of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Hugh WatkinsWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
David P StrachanPopulation Health Research Institute, St George's, University of London, London, SW17 0RE, UK.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Peter SeverNational Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.
Neil PoulterSchool of Public Health, Imperial College London, London, W12 7RH, UK.
Lee-Ming ChuangDepartment of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Thomas M DantoftCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Fredrik KarpeOCDEM, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
Matt J NevilleOCDEM, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
Nicholas J TimpsonMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
Ching-Yu ChengOcular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
Tien-Yin WongOcular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
Chiea Chuen KhorGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Hengtong LiData Science, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
Charumathi SabanayagamOcular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Andrew T HattersleyMedical School, University of Exeter, University of Exeter, Exeter, EX2 5DW, UK.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Allegonda H M WillemsenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
LAdrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Mohsen GhanbariDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Penny Gordon-LarsenDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.
Wei HuangDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China.
Young Jin KimDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Eleftheria ZegginiWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Goncalo AbecasisDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Scott HazelhurstSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Michèle RamsaySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Martha DaviglusInstitute for Minority Health Research, University of Illinois College of Medicine, Chicago, IL, USA.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia.
John B WhitfieldQIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia.
Shahid AbbasCenter for Non-Communicable Diseases, Karachi, Sindh, Pakistan.
Danish SaleheenCenter for Non-Communicable Diseases, Karachi, Sindh, Pakistan.
Robin G WaltersClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Michael V HolmesClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Corri BlackAberdeen Centre for Health Data Science,1:042 Polwarth Building School of Medicine, Medical Science and Nutrition University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
Blair H SmithDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
Aris BarasRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Anne E JusticeDepartment of Population Health Sciences, Geisinger Health, Danville, PA, 17822, USA.
Julie E BuringDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Charles KooperbergFred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA, 9810, USA.
Gen TamiyaTohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Masayuki YamamotoTohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
David A van HeelBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Richard C TrembathSchool of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Wei-Qi WeiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Gail P JarvikDepartments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Washington, USA.
Bahram NamjouCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
M Geoffrey HayesCenter for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60618, USA.
Marylyn D RitchieDepartment of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Pekka JousilahtiDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Veikko SalomaaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Bjørn Olav ÅsvoldK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Yoshinori MurakamiDivision of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Bong-Jo KimDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Unnur ThorsteinsdottirdeCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.
Kari StefanssondeCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.
Jifeng ZhangDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
YEugene ChenDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Yuk-Lam HoVA Boston Healthcare System, Boston, MA, USA.
Julie A LynchVA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
Daniel J RaderDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Philip S TsaoVA Palo Alto Health Care Systems, Palo Alto, CA, USA.
Kyong-Mi ChangCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Kelly ChoVA Boston Healthcare System, Boston, MA, USA.
Christopher J O'DonnellVA Boston Healthcare System, Boston, MA, USA.
John M GazianoVA Boston Healthcare System, Boston, MA, USA.
Peter W F WilsonAtlanta VA Health Care System, Decatur, GA, USA.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Joel N HirschhornBoston Children's Hospital, EndocrinologyBoston, MA, 02115, USA.
Sekar KathiresanProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Andrew P MorrisCentre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.
Michael Boehnke *Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Christopher D Brown *Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Pradeep Natarajan *Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Panos Deloukas *William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Cristen J Willer *Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA. cristen@umich.edu.
Themistocles L Assimes *VA Palo Alto Health Care Systems, Palo Alto, CA, USA.
Gina M Peloso *Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA. gpeloso@bu.edu.ORCID 0000-0002-5355-8636
University of Michigan · USQueen Mary University of London · GBBroad Institute · USUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USBrigham and Women's Hospital · USUniversity of Copenhagen · DKUtrecht University · NLAgency for Science, Technology and Research · SGLeiden University Medical Center · NLThe Lundquist Institute · USUniversity of Helsinki · FIWestern General Hospital · GBChinese Academy of Medical Sciences & Peking Union Medical College · CNdeCODE Genetics (Iceland) · ISErasmus MC · NLKorea National Institute of Health · KRRadboud University Nijmegen · NLUniversity Medical Center Groningen · NLBoston University · US
Funding
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY E. PESSIN · 2015 to 2026
$27.7MMONITORING SOCIAL CHANGE: HEALTH, REPRODUCTION, AGINGR01HD030880 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADAIR, LINDA S, POPKIN, BARRY M · 1994 to 2024
$27.0MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MUniversity of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4MCell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1MShared Core: Biobanking, Bioinformatics and Data ManagementU54HG006938 · NHGRI · WITS HEALTH CONSORTIUM (PTY), LTD · PI RAMSAY, MICHELE MICHELE · 2012 to 2022
$12.2MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MBLRD VA I01 BX003340BLRD VA I01 BX004821British Heart Foundation FS/14/66/3129British Heart Foundation RG/14/5/30893Cancer Research UK C18281/A19169CSRD VA IK2 CX001780Department of Health BRC-1215-2001Intramural NIH HHS Z01 HG200362Medical Research Council G0601463Medical Research Council MC_PC_20026Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00011Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00019/1Medical Research Council MR/R024227/1Medical Research Council MR/S011676/1NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS UM1 CA182876NHGRI NIH HHS T32 HG000040NHGRI NIH HHS U01 HG011172NHGRI NIH HHS U01 HG011723NHGRI NIH HHS U54 HG006938NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL153805NHLBI NIH HHS R01 HL163854NHLBI NIH HHS R03 HL154284NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG065357NICHD NIH HHS R01 HD030880NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK093757Wellcome Trust 201543/B/16/ZWellcome Trust 202802/Z/16/ZWellcome Trust 210561/Z/18/ZWellcome Trust 212945/Z/18/ZWellcome Trust 217065/Z/19/Z
Abstract
backgroundGenetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.
resultsTo expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.
conclusionsTaken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyGenetic PleiotropyHumansLipidsPhenotypePolymorphism, Single NucleotideSex CharacteristicsLipidsCholesterolGeneticsGenome-wide association studyGWASLipids
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