Evidence map›Paper›PMID 36575386›Full record

ArticleBMC genomics2022

Differential Grainy head binding correlates with variation in chromatin structure and gene expression in Drosophila melanogaster.

Henry A Ertl, Mark S Hill, Patricia J Wittkopp

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Henry A ErtlDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
Mark S HillDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
Patricia J WittkoppDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, 48109, USA. wittkopp@umich.edu.
University of Michigan–Ann Arbor · USUniversity College London · GB

Funding

Genetic mechanisms and evolutionary processes underlying diversity within and between speciesR35GM118073 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WITTKOPP, PATRICIA JEAN · 2016 to 2025
$4.1M
NIGMS NIH HHS R35 GM118073
6 · The paper itself

Abstract

Phenotypic evolution is often caused by variation in gene expression resulting from altered gene regulatory mechanisms. Genetic variation affecting chromatin remodeling has been identified as a potential source of variable gene expression; however, the roles of specific chromatin remodeling factors remain unclear. Here, we address this knowledge gap by examining the relationship between variation in gene expression, variation in chromatin structure, and variation in binding of the pioneer factor Grainy head between imaginal wing discs of two divergent strains of Drosophila melanogaster and their F

Indexed as

Drosophila melanogasterDrosophila ProteinsAnimalsChromatinDNA-Binding ProteinsGene ExpressionTranscription FactorsChromatinDNA-Binding ProteinsDrosophila ProteinsTranscription FactorsChromatin accessibilityEvolutionPioneer factorTranscription factor

Identifiers

PMID36575386
PMCPMC9795675
OpenAlexW4313249611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.