ArticleAlcohol, clinical & experimental research2023
Sex differences in neuronal activation during aversion-resistant alcohol consumption.
Article in Alcohol, clinical & experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Alcohol abstinence precipitates alcohol seeking and aversion-resistant intake in association with increased BNST activity.Molecular psychiatry · 2026Article
- Individual differences in ethanol drinking meal structure are shaped by social environments.bioRxiv : the preprint server for biology · 2026Article
- Attenuated conditioned taste aversion for sucrose in female mice with a history of chronic low-dose ethanol exposure.bioRxiv : the preprint server for biology · 2026Article
- Activation of a locus coeruleus to ventral tegmental area noradrenergic pathway blunts binge-like ethanol intake and promotes aversive unconditioned responses in TH-ires-Cre mice.Neuropharmacology · 2026Article
- Adolescent onset of volitional ethanol intake normalizes sex differences observed with adult-onset ethanol intake and negative affective behaviors during protracted forced abstinence.Psychopharmacology · 2026Article
- Prelimbic cortex, but not its nucleus reuniens projections, regulates punished alcohol self-administration.Neuropharmacology · 2026Article
- Sex-Specific patterns of vulnerability to alcohol addiction-like behaviors in rats.Translational psychiatry · 2026Article
- Lateral hypothalamus CRFR1 regulation of chronic binge drinking: divergence along anterior-posterior axis.bioRxiv : the preprint server for biology · 2025Article
- Individual differences in punished alcohol self-administration are unaltered by alcohol vapor exposure.Alcohol (Fayetteville, N.Y.) · 2025Observational
- Effect of acute alcohol consumption in a novel rodent model of decision-making.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Article
- Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking.Alcohol (Fayetteville, N.Y.) · 2025Article
- Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking.Pharmacology, biochemistry, and behavior · 2025Article
- Individual and sex differences in frontloading behavior and approach- avoidance conflict preference predict addiction-like ethanol seeking in rats.Scientific reports · 2025Article
- Sex Differences in Mouse Models of Voluntary Alcohol Drinking and Abstinence-Induced Negative Emotion.Alcohol (Fayetteville, N.Y.) · 2024Review
- Punishment-resistant alcohol intake is mediated by the nucleus accumbens shell in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Identification of Phosphodiesterase-7A (PDE7A) as a Novel Target for Reducing Ethanol Consumption in Mice.The international journal of neuropsychopharmacology · 2024Article
- Sex differences in neuronal activation in the cortex and midbrain during quinine-adulterated alcohol intake.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Different mechanisms underlie compulsive alcohol self-administration in male and female rats.Biology of sex differences · 2024Article
- Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice.Neuropharmacology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOne of the DSM-5 criteria for Alcohol Use Disorder is continued alcohol consumption despite negative consequences. This has been modeled in mice using adulteration of alcohol solution with the bitter tastant quinine. Mice that continue to consume alcohol despite this adulteration are considered aversion resistant. The limited number of studies dissecting the underlying neuronal mechanisms of aversion-resistant drinking behaviors used only male subjects. We have previously shown that female mice are more resistant to quinine adulteration of alcohol than males. Our aim here is to identify potential sex differences in neuronal activation that may underlie this behavior.
methodsMale and female C57BL/6J mice were allowed continuous access to 20% alcohol in a two-bottle choice procedure. To test aversion-resistance, the alcohol was adulterated with increasing concentrations (0.03, 0.1, and 0.2 mM) of quinine hydrochloride. After consumption rates were calculated, brains were extracted to examine neuronal activation using Fos immunohistochemistry.
resultsWe found that female mice suppressed their intake to a lesser extent than males when the alcohol solution was adulterated with quinine. Our Fos staining revealed three regions of interest that exhibit a sex difference during quinine-adulterated alcohol drinking: the ventromedial prefrontal cortex (vmPFC), the posterior insular cortex (PIC), and the ventral tegmental area (VTA). Both the vmPFC and the PIC exhibited higher neuronal activation in males during quinine-adulterated alcohol consumption. However, females showed higher Fos activation in the VTA during quinine-adulterated alcohol consumption.
conclusionsFemales more readily exhibit aversion-resistant alcohol intake than their male counterparts and exhibit some differences in neuronal activation patterns. We conclude that there are sex differences in neurocircuitry that may underlie compulsive drinking behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.