Evidence map›Paper›PMID 36575048›Full record

ArticleAging2022

Exosomes derived from human umbilical cord mesenchymal stem cells promote osteogenesis through the AKT signaling pathway in postmenopausal osteoporosis.

Shi-Wei Ren, Guang-Qing Cao, Qing-Run Zhu, Min-Gang He, Fang Wu, Su-Mei Kong, Zhao-Yan Zhang, Qiang Wang, Feng Wang

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Shi-Wei RenDepartment of Orthopedics, The Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250014, Shandong, China.
Guang-Qing CaoDepartment of Spine Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China.
Qing-Run ZhuDepartment of Orthopedics, The Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250014, Shandong, China.
Min-Gang HeDepartment of Gastrointestinal Surgery, Shandong Tumor Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China.
Fang WuDepartment of Health, 960th Hospital of PLA, Jinan 250031, Shandong, China.
Su-Mei KongDepartment of Health, 960th Hospital of PLA, Jinan 250031, Shandong, China.
Zhao-Yan ZhangDepartment of Health, 960th Hospital of PLA, Jinan 250031, Shandong, China.
Qiang WangDepartment of Orthopedics, The Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250014, Shandong, China.
Feng WangDepartment of Orthopedics, The Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250014, Shandong, China.
82th Hospital of Pla · CNShandong First Medical University · CNShandong Provincial Hospital · CNSecond Hospital of Shandong University · CNShandong Tumor Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postmenopausal osteoporosis (PMO) is a relatively common disease characterized by low bone mass and microstructural changes of trabecular bone. The reduced bone strength is caused a variety of complications, including fragility fracture and sarcopenia. We used CCK-8 and EdU assays to evaluate cell proliferation rates. The osteogenesis effect was detected using ALP staining, alizarin red staining, and q-PCR.

Indexed as

ExosomesMesenchymal Stem CellsOsteoporosis, PostmenopausalFemaleHumansOsteogenesisProto-Oncogene Proteins c-aktSignal TransductionUmbilical CordProto-Oncogene Proteins c-aktexosomeshuman umbilical cord mesenchymal stem cellsosteogenesispostmenopausal osteoporosis

Identifiers

PMID36575048
PMCPMC9831744
OpenAlexW4313249141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.