Evidence map›Paper›PMID 36574699›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Distinct ecological fitness factors coordinated by a conserved

Nicky O'Boyle, Gillian R Douce, Gillian Farrell, Nicholas J W Rattray, Mark A Schembri, Andrew J Roe, James P R Connolly

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Nicky O'BoyleSchool of Microbiology, University College Cork, National University of Ireland, Cork T12 K8AF, Ireland.
Gillian R DouceInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, United Kingdom.
Gillian FarrellStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom.
Nicholas J W RattrayStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom.ORCID 0000-0002-3528-6905
Mark A SchembriSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-4863-9260
Andrew J RoeInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, United Kingdom.ORCID 0000-0003-3698-6134
James P R ConnollyNewcastle University Biosciences Institute, Newcastle University, Newcastle-upon-Tyne NE2 4HH, United Kingdom.ORCID 0000-0002-0394-3413
University of Glasgow · GBUniversity of Strathclyde · GBNational University of Ireland · IENewcastle University · GBThe University of Queensland · AU

Funding

Biotechnology and Biological Sciences Research Council BB/R006539/1Wellcome Trust 204877/Z/16/Z
6 · The paper itself

Abstract

The ability of bacterial pathogens to adapt to host niches is driven by the carriage and regulation of genes that benefit pathogenic lifestyles. Genes that encode virulence or fitness-enhancing factors must be regulated in response to changing host environments to allow rapid response to challenges presented by the host. Furthermore, this process can be controlled by preexisting transcription factors (TFs) that acquire new roles in tailoring regulatory networks, specifically in pathogens. However, the mechanisms underlying this process are poorly understood. The highly conserved

Indexed as

Escherichia coli InfectionsEscherichia coli ProteinsSepsisUrinary Tract InfectionsUropathogenic Escherichia coliAnimalsEscherichia coliGene Expression Regulation, BacterialMiceVirulence FactorsEscherichia coli ProteinsVirulence FactorsbloodstreamEscherichia colifimbriaeregulationtryptophan

Identifiers

PMID36574699
PMCPMC9910484
OpenAlexW4313251038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.