ArticleProceedings of the National Academy of Sciences of the United States of America2023
Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Incidence of dementia and mild cognitive impairment in two Indigenous Bolivian cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Genetic Determinants of Infectious Diseases in the Qatari Population.Epidemiologia (Basel, Switzerland) · 2026Article
- Article
- Segmentation and morphometry of intracranial internal carotid artery calcification in relation to brain atrophy.Neuroradiology · 2026Article
- Unlocking Ethiopia's genomic landscape and its global significance: a call for inclusive genomics research.Human genomics · 2026Review
- Natural selection exerted by historical coronavirus epidemic(s): comparative genetic analysis in China Kadoorie Biobank and UK Biobank.BMC genomics · 2025Article
- Ectopic adipose tissue in subsistence populations with minimal coronary disease, large left atria, and very low rates of atrial fibrillation.American journal of preventive cardiology · 2025Article
- Nonuniversality of inflammaging across human populations.Nature aging · 2025Article
- Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon.Proceedings. Biological sciences · 2025Article
- Cost-effective solutions for high-throughput enzymatic DNA methylation sequencing.PLoS genetics · 2025Article
- Characterizing substructure via mixture modeling in large-scale genetic summary statistics.American journal of human genetics · 2025Article
- Higher blood lipid levels after the transition to menopause in two forager-horticulturalist populations.Evolution, medicine, and public health · 2025Article
- Increases in regional brain volume across two native South American male populations.GeroScience · 2024Article
- Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources.BMC genomics · 2024Article
- Characterizing substructure via mixture modeling in large-scale genetic summary statistics.bioRxiv : the preprint server for biology · 2024Article
- Poor Oral Health Is Associated With Inflammation, Aortic Valve Calcification, and Brain Volume Among Forager-Farmers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease risk.Evolution, medicine, and public health · 2024Review
- Increasing diversity of functional genetics studies to advance biological discovery and human health.American journal of human genetics · 2023Article
- Article
- Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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17 authors.
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Abstract
A growing body of work has addressed human adaptations to diverse environments using genomic data, but few studies have connected putatively selected alleles to phenotypes, much less among underrepresented populations such as Amerindians. Studies of natural selection and genotype-phenotype relationships in underrepresented populations hold potential to uncover previously undescribed loci underlying evolutionarily and biomedically relevant traits. Here, we worked with the Tsimane and the Moseten, two Amerindian populations inhabiting the Bolivian lowlands. We focused most intensively on the Tsimane, because long-term anthropological work with this group has shown that they have a high burden of both macro and microparasites, as well as minimal cardiometabolic disease or dementia. We therefore generated genome-wide genotype data for Tsimane individuals to study natural selection, and paired this with blood mRNA-seq as well as cardiometabolic and immune biomarker data generated from a larger sample that included both populations. In the Tsimane, we identified 21 regions that are candidates for selective sweeps, as well as 5 immune traits that show evidence for polygenic selection (e.g., C-reactive protein levels and the response to coronaviruses). Genes overlapping candidate regions were strongly enriched for known involvement in immune-related traits, such as abundance of lymphocytes and eosinophils. Importantly, we were also able to draw on extensive phenotype information for the Tsimane and Moseten and link five regions (containing
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