Evidence map›Paper›PMID 36574660›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.

Andrew R Castle, Sang-Gyun Kang, Ghazaleh Eskandari-Sedighi, Serene Wohlgemuth, My-Anh Nguyen, Daniel J Drucker, Erin E Mulvihill, David Westaway

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: Implications for prion diseases.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Andrew R CastleCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 2M8, Canada.ORCID 0000-0003-2590-9555
Sang-Gyun KangCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 2M8, Canada.ORCID 0000-0002-6875-113X
Ghazaleh Eskandari-SedighiCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 2M8, Canada.ORCID 0000-0003-0447-7722
Serene WohlgemuthCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 2M8, Canada.
My-Anh NguyenUniversity of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada.
Daniel J DruckerLunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-6688-8127
Erin E MulvihillUniversity of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada.ORCID 0000-0002-3981-0241
David WestawayCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 2M8, Canada.ORCID 0000-0003-1928-4616
University of Alberta · CAUniversity of Ottawa · CAUniversity of Toronto · CA

Funding

CIHR 154321CIHR 156136CIHR PS165980
6 · The paper itself

Abstract

The cellular prion protein (PrP

Indexed as

Prion DiseasesPrionsPrPC ProteinsAnimalsDipeptidyl Peptidase 4FibroblastsHumansMicePeptide HydrolasesPrion ProteinsSerine EndopeptidasesDipeptidyl Peptidase 4Peptide HydrolasesPrion ProteinsPrionsPrPC ProteinsSerine Endopeptidasesbeta-cleavagedipeptidyl peptidaseDPP4prion diseaseprolyl endopeptidase FAP

Identifiers

PMID36574660
PMCPMC9910601
OpenAlexW4313251449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.