SynthesisAesthetic plastic surgery2024
Administration Method and Potential Efficacy of Hyaluronidase for Hyaluronic Acid Filler-Related Vision Loss: A Systematic Review.
Synthesis in Aesthetic plastic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Anatomical Guideline for Retrobulbar Hyaluronidase Injection.Journal of cosmetic dermatology · 2025Guideline
- Review
- Single-Center Retrospective Case Series of 33 Patients with Ophthalmic-Cerebral Embolic Stroke Following Cosmetic Facial Injection, 2017-2025.Healthcare (Basel, Switzerland) · 2026Article
- Agarose Gel as an Injectable Filler Significantly Reduced the Risk of Rabbit Retinal Artery Embolism Compared to Hyaluronic Acid.Aesthetic plastic surgery · 2026Article
- Management of Visual Loss Following Hyaluronic Acid Filler Injections: An Algorithm-based Approach.Plastic and reconstructive surgery. Global open · 2026Article
- Ultrasound observational anatomical guideline for retrobulbar hyaluronidase injection.Anatomy & cell biology · 2025Review
- Nonsurgical Approach to Treat Post-Rhinoplasty Vascular Complication With Hyaluronic Acid Injection.Journal of cosmetic dermatology · 2025Article
- Management of vision loss associated with complications of cosmetic filler injections.Frontiers in ophthalmology · 2025Review
- A comprehensive review on microbial hyaluronan-degrading enzymes: from virulence factors to biotechnological tools.Bioresources and bioprocessing · 2024Review
- Pectoral Nerve Blocks Under Direct Vision During Endoscopic-Assisted Transaxillary Breast Augmentation: A Novel, Effective Regional Blocking Approach.Aesthetic plastic surgery · 2024Article
- Adverse Effects Associated with Dermal Filler Treatments: Part II Vascular Complication.Diagnostics (Basel, Switzerland) · 2024Review
- Letter on Nasal Reconstruction Using Rib Grafting with Cold Light Source Technology.Aesthetic plastic surgery · 2024Article
- Retinal artery occlusion after facial filler injection in a patient with patent foramen ovale: a case report and literature review.The Journal of international medical research · 2023Review
- Clinical Manifestations and Prognosis of Embolism Caused by Filler Injection in Different Facial Regions.Plastic and reconstructive surgery. Global open · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWith the global increase in the use of injectable fillers, more cases with serious adverse events such vision loss are being reported. This article aims to review the cases of hyaluronic acid (HA) filler-related vision loss and to discuss the potential efficacy of hyaluronidase (HYASE) treatment via different given methods.
methodsA total of 29 articles presenting 144 cases of HA filler-related vision loss were included in this study.
resultsMost cases of HA filler-related vision impairment were reported from China, followed by Korea. The majority of cases were seen in women. The nose, forehead and glabella were the most commonly injection sites. All cases had vision impairment and nearly all cases were unilateral with immediate onset of visual signs and symptoms. Ophthalmic artery occlusion (OAO) and central retinal artery occlusion (CRAO) were the two most commonly involved arterial obstruction patterns featured with a very poor prognosis followed by branch retinal artery occlusion (BRAO), the most favorable involved arterial pattern for a better prognosis. HYASE given subcutaneously and intra-arterially helped with visual recovery to different degrees, while retrobulbar HYASE seemed to be less helpful.
conclusionComplications after HA-based filler injection are extremely rare but can cause disastrous visual impairment. HYASE given subcutaneously and intra-arterially helped with visual recovery to different extents, and the efficacy might be reinforced when performed together, while retrobulbar HYASE seemed to be less helpful. However, to accurately access the efficacy of HYASE via different administration methods, further randomized controlled trials are needed. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.