Evidence map›Paper›PMID 36573725›Full record

ArticleJournal of personalized medicine2022

In Vivo Validation of a Novel Computational Approach to Assess Microcirculatory Resistance Based on a Single Angiographic View.

Yongzhen Fan, Simone Fezzi, Pengcheng Sun, Nan Ding, Xiaohui Li, Xiaorong Hu, Shuang Wang, William Wijns, Zhibing Lu, Shengxian Tu

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05671367 (Evaluation of the Correlation Between Coronary Microvascular Resistance Based on Quantitative Flow Ratio and Major Adverse Cardiovascular Events in Patients With Obstructive Hypertrophic Cardiomyopathy), which is not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05671367 completednot on this map

Evaluation of the Correlation Between Coronary Microvascular Resistance Based on Quantitative Flow Ratio and Major Adverse Cardiovascular Events in Patients With Obstructive Hypertrophic Cardiomyopathy: A Retrospective Cohort Study

TypeobservationalSponsorChina National Center for Cardiovascular DiseasesRan2017 to 2022Enrolled340ConditionsMicrovascular Dysfunction, Hypertrophic Obstructive Cardiomyopathy, Microcirculation Resistance
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Cocaine-induced acute myocardial infarction: angiographic features and outcomes.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Observational
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Observational

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yongzhen FanDepartment of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Simone FezziThe Lambe Institute for Translational Medicine, the Smart Sensors Lab and Curam, University of Galway, University Road, H91 TK3 Galway, Ireland.ORCID 0000-0003-2755-2094
Pengcheng SunShanghai Pulse Medical Technology Inc., Shanghai 200233, China.ORCID 0000-0002-7750-0551
Nan DingShanghai Pulse Medical Technology Inc., Shanghai 200233, China.
Xiaohui LiShanghai Pulse Medical Technology Inc., Shanghai 200233, China.
Xiaorong HuDepartment of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Shuang WangDepartment of Cardiovascular Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
William WijnsThe Lambe Institute for Translational Medicine, the Smart Sensors Lab and Curam, University of Galway, University Road, H91 TK3 Galway, Ireland.
Zhibing LuDepartment of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Shengxian TuBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0001-9681-1067

Funding

Science and Technology Commission of Shanghai Municipality 21JC1405300Science Foundation Ireland Research Professorship Award 15/RP/2765
6 · The paper itself

Abstract

(1) Background: In spite of the undeniable clinical value of the index of microvascular resistance (IMR) in assessing the status of coronary microcirculation, its use globally remains very low. The aim of this study was to validate the novel single-view, pressure-wire- and adenosine-free angiographic microvascular resistance (AMR) index, having the invasive wire-based IMR as a reference standard. (2) Methods: one hundred and sixty-three patients (257 vessels) were investigated with pressure wire-based IMR. Microvascular dysfunction (CMD) was defined by IMR ≥ 25. AMR was independently computed from the diagnostic coronary angiography in a blinded fashion. (3) Results: AMR demonstrated a good correlation (r = 0.83, p < 0.001) and diagnostic performance (AUC 0.94; 95% CI: 0.91 to 0.97) compared with wire-based IMR. The best cutoff value for AMR in determining IMR ≥ 25 was 2.5 mmHg*s/cm. The overall diagnostic accuracy of AMR was 87.2% (95% CI: 83.0% to 91.3%), with a sensitivity of 93.5% (95% CI: 87.0% to 97.3%), a specificity of 82.7% (95% CI: 75.6% to 88.4%), a positive predictive value of 79.4% (95% CI: 71.2% to 86.1%) and a negative predictive value of 94.7% (95% CI: 89.3% to 97.8%). No difference in terms of CMD rate was described among different clinical presentations. (4) Conclusions: AMR derived solely from a single angiographic view is a feasible computational alternative to pressure wire-based IMR, with good diagnostic accuracy in assessing CMD.

Indexed as

angiography-derived physiologycoronary physiologycoronary pressure and flowfunctional coronary angiographyischemia with non-obstructed coronary artery diseasemicrovascular dysfunctionmyocardial microcirculationpersonalized invasive therapy in coronary artery disease

Identifiers

PMID36573725
PMCPMC9692562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.