Evidence map›Paper›PMID 36573722›Full record

ArticleJournal of personalized medicine2022

COVID-19 Impact on Chronic Myeloid Leukemia Patients.

Dana Raluca Arbore, Simona Maria Galdean, Delia Dima, Ioana Rus, David Kegyes, Raluca Geanina Ababei, Daniela Dragancea, Radu Andrei Tomai, Adrian Pavel Trifa, Ciprian Tomuleasa

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dana Raluca ArboreDepartment of Hematology, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Simona Maria GaldeanDepartment of Hematology, Ion Chiricuta Clinical Cancer Center, 400012 Cluj-Napoca, Romania.
Delia DimaDepartment of Hematology, Ion Chiricuta Clinical Cancer Center, 400012 Cluj-Napoca, Romania.
Ioana RusDepartment of Hematology, Ion Chiricuta Clinical Cancer Center, 400012 Cluj-Napoca, Romania.
David KegyesDepartment of Hematology, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0002-6252-6281
Raluca Geanina AbabeiDepartment of Hematology, Ion Chiricuta Clinical Cancer Center, 400012 Cluj-Napoca, Romania.
Daniela DraganceaDepartment of Hematology, Ion Chiricuta Clinical Cancer Center, 400012 Cluj-Napoca, Romania.
Radu Andrei TomaiDepartment of Hematology, Ion Chiricuta Clinical Cancer Center, 400012 Cluj-Napoca, Romania.
Adrian Pavel TrifaDepartment of Hematology, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0002-0229-8643
Ciprian TomuleasaDepartment of Hematology, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-5500-1519
Institute of Oncology Prof. Dr. Ion Chiricuta · ROIuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

Iuliu Hațieganu University of Medicine and Pharmacy 1680/22/19.01.2018
6 · The paper itself

Abstract

(1) Background: Chronic myeloid leukemia (CML) is a blood dyscrasia that accounts for about 20% of all leukemia cases. Tyrosine kinase inhibitors (TKIs) are used as first line treatment of CML. The 2019 SARS-CoV-2 outbreak raised new concerns for CML patients, such as whether CML increases the risk of contracting COVID-19, whether TKIs increase that risk, whether these drugs are safe to use during the infection, and whether any other hematologic parameters influence infection outcomes. (2) Methods: In our study we addressed these intriguing questions by using a retrospective analysis of 51 CML patients treated at the Ion Chiricuta Cancer Center, Cluj-Napoca, Romania. Furthermore, we investigated the effects of currently approved COVID-19 vaccines in our CML patients treated with tyrosine kinase inhibitors. (3) Results: Our results have shown that hemoglobin level upon diagnosis of CML has been the only hematologic parameter correlated to the risk of contracting COVID-19 in our CML patients. (4) Conclusions: TKI treatment did not negatively influence COVID-19 risk or the response to the vaccine in our patients. The safety profile of the currently approved COVID-19 vaccines was similar to that of the general population.

Indexed as

chronic myeloid leukemiaCOVID-19COVID-19 vaccineSARS-Cov-2tyrosine kinase inhibitors

Identifiers

PMID36573722
PMCPMC9699250
OpenAlexW4308872786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.