ArticleCerebral cortex (New York, N.Y. : 1991)2023
Single voxel autocorrelation uncovers gradients of temporal dynamics in the hippocampus and entorhinal cortex during rest and navigation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Age Differences in Hippocampal Neural Timescales During Movie-Viewing.bioRxiv : the preprint server for biology · 2026Article
- The Development of Hippocampal-Cortical Functional Connectivity in Infants and Toddlers.Human brain mapping · 2026Article
- Graded encoding of spatial novelty scales in the human brain.Nature communications · 2025Article
- Hippocampal Drift Rate Reflects the Temporal Organization of Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
- Rapid learning of temporal dependencies at multiple timescales.bioRxiv : the preprint server for biology · 2024Article
- Differential involvement of the anterior and posterior hippocampus, parahippocampus, and retrosplenial cortex in making precise judgments of spatial distance and object size for remotely acquired memories of environments and objects.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Goal-oriented representations in the human hippocampus during planning and navigation.Nature communications · 2023Article
- Transcranial magnetic stimulation to the angular gyrus modulates the temporal dynamics of the hippocampus and entorhinal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Data-Driven Clustering of Functional Signals Reveals Gradients in Processing Both within the Anterior Hippocampus and across Its Long Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Single voxel autocorrelation reflects hippocampal function in temporal lobe epilepsy.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
During navigation, information at multiple scales needs to be integrated. Single-unit recordings in rodents suggest that gradients of temporal dynamics in the hippocampus and entorhinal cortex support this integration. In humans, gradients of representation are observed, such that granularity of information represented increases along the long axis of the hippocampus. The neural underpinnings of this gradient in humans, however, are still unknown. Current research is limited by coarse fMRI analysis techniques that obscure the activity of individual voxels, preventing investigation of how moment-to-moment changes in brain signal are organized and how they are related to behavior. Here, we measured the signal stability of single voxels over time to uncover previously unappreciated gradients of temporal dynamics in the hippocampus and entorhinal cortex. Using our novel, single voxel autocorrelation technique, we show a medial-lateral hippocampal gradient, as well as a continuous autocorrelation gradient along the anterolateral-posteromedial entorhinal extent. Importantly, we show that autocorrelation in the anterior-medial hippocampus was modulated by navigational difficulty, providing the first evidence that changes in signal stability in single voxels are relevant for behavior. This work opens the door for future research on how temporal gradients within these structures support the integration of information for goal-directed behavior.
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