ArticleMolecular autism2022
Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder.
Article in Molecular autism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Distinct features of EEG microstates in autism spectrum disorder revealed by meta-analysis: the contribution of individual age to heterogeneity across studies.Frontiers in psychiatry · 2025Pooled it
- Myelin, white matter, and social deficits in autism spectrum disorder.Neural regeneration research · 2026Article
- Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- From heterogeneity to translation: data‑driven subtyping of autism in a multilevel framework.Translational psychiatry · 2026Review
- Aberrant multivariate mapping between behavioral profiles and cortical morphological brain networks in children with autism spectrum disorder.Translational psychiatry · 2026Article
- Autism Spectrum Disorder-Associated Genes Enrich in Discrete Cortical, Limbic and Cerebellar Brain Regions.The European journal of neuroscience · 2026Article
- Age-stratified individual-specific subspace of autism spectrum disorder based on common orthogonal basis extraction algorithm improves the accuracy of clinical symptoms prediction.BMC psychiatry · 2026Article
- Diminished Signal-to-Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Machine-enhanced reconstruction of functional connectomes unravels discriminative brain sub-systems in health and disease.Scientific reports · 2026Article
- Common and distinct changes of regional resting-state brain activity between high- and low-functioning autism spectrum disorder.BMC psychiatry · 2026Article
- Identifying Two Autism Biotypes Using Multi-Task Learning Derived Individual-Specific Functional Connectivity.Journal of autism and developmental disorders · 2026Article
- Atypical development of white matter structural networks in children and adolescents with autism spectrum disorder: a graph theory study.Frontiers in neuroscience · 2026Article
- Subtyping Autism Spectrum Disorder With a Population Graph-Based Dual Autoencoder: Revealing Two Distinct Biotypes.CNS neuroscience & therapeutics · 2025Article
- Inter-brain synchrony to delineate the social impairment in autism spectrum disorder: a systematic review on hyperscanning studies.Psychoradiology · 2025Review
- Sex differences in the flexibility of dynamic network reconfiguration of autism spectrum disorder based on multilayer network.Brain imaging and behavior · 2024Article
- A clustering approach identifies an Autism Spectrum Disorder subtype more responsive to chronic oxytocin treatment.Translational psychiatry · 2024Article
- Individual Deviation-Based Functional Hypergraph for Identifying Subtypes of Autism Spectrum Disorder.Brain sciences · 2024Article
- Paradigm shift required for translational research on the brain.Experimental & molecular medicine · 2024Review
- Delineating Transdiagnostic Subtypes in Neurodevelopmental Disorders via Contrastive Graph Machine Learning of Brain Connectivity Patterns.bioRxiv : the preprint server for biology · 2024Article
- Exome functional risk score and brain connectivity can predict social adaptability outcome of children with autism spectrum disorder in 4 years' follow up.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical heterogeneity. This study aimed to explore the heterogeneity of ASD based on inter-individual heterogeneity of functional brain networks.
methodsResting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange database were used in this study for 105 children with ASD and 102 demographically matched typical controls (TC) children. Functional connectivity (FC) networks were first obtained for ASD and TC groups, and inter-individual deviation of functional connectivity (IDFC) from the TC group was then calculated for each individual with ASD. A k-means clustering algorithm was used to obtain ASD subtypes based on IDFC patterns. The FC patterns were further compared between ASD subtypes and the TC group from the brain region, network, and whole-brain levels. The relationship between IDFC and the severity of clinical symptoms of ASD for ASD subtypes was also analyzed using a support vector regression model.
resultsTwo ASD subtypes were identified based on the IDFC patterns. Compared with the TC group, the ASD subtype 1 group exhibited a hypoconnectivity pattern and the ASD subtype 2 group exhibited a hyperconnectivity pattern. IDFC for ASD subtype 1 and subtype 2 was found to predict the severity of social communication impairments and the severity of restricted and repetitive behaviors in ASD, respectively. LIMITATIONS: Only male children were selected for this study, which limits the ability to study the effects of gender and development on ASD heterogeneity.
conclusionsThese results suggest the existence of subtypes with different FC patterns in ASD and provide insight into the complex pathophysiological mechanism of clinical manifestations of ASD.
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