Evidence map›Paper›PMID 36572788›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2023

The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument.

Qiang Zheng, Ingrid A Cox, Barbara de Graaff, Julie A Campbell, Tamera J Corte, Ian Glaspole, Vidya Navaratnam, Peter Hopkins, Chris Zappala, Hasnat Ahmad and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Comorbidities in clinical cohorts of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Qiang ZhengMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia.
Ingrid A CoxMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia.
Barbara de GraaffMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia.
Julie A CampbellMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia.
Tamera J CorteNHMRC Centre of Research Excellence for Pulmonary Fibrosis, Camperdown, NSW, Australia.
Ian GlaspoleNHMRC Centre of Research Excellence for Pulmonary Fibrosis, Camperdown, NSW, Australia.
Vidya NavaratnamAustralian Idiopathic Pulmonary Fibrosis Registry, Lung Foundation of Australia, Camperdown, NSW, Australia.
Peter HopkinsNHMRC Centre of Research Excellence for Pulmonary Fibrosis, Camperdown, NSW, Australia.
Chris ZappalaDepartment of Thoracic Medicine, Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia.
Hasnat AhmadMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia.
Ting ZhaoMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia.
Sacha MacanshAustralian Idiopathic Pulmonary Fibrosis Registry, Lung Foundation of Australia, Camperdown, NSW, Australia.
E Haydn Walters *Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia.
Andrew J Palmer *Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia. andrew.palmer@utas.edu.au.
National Health and Medical Research Council · AUUniversity of Tasmania · AUCooperative Trials Group for Neuro-Oncology · AULung Foundation Australia · AURoyal Brisbane and Women's Hospital · AUThe Alfred Hospital · AUUniversity of Queensland · AU

Funding

the NHMRC Centre of Research Excellence in Pulmonary Fibrosis GNT1116371
6 · The paper itself

Abstract

purposeLittle is known about the impact of co-morbidities on health-related quality of life (HRQoL) for people with idiopathic pulmonary fibrosis (IPF). We aimed to investigate the relative contribution of co-morbidities to HRQoL of people with IPF.

methodsN = 157 participants were recruited from the Australian IPF Registry (AIPFR). Health state utilities (HSUs), and the super-dimensions of physical and psychosocial scores were measured using the Assessment of Quality of Life-8-Dimensions (AQoL-8D). The impact of co-morbidities on HRQoL was investigated using linear regression and general dominance analyses.

resultsA higher number of co-morbidities was associated with lower HSUs (p trend = 0.002). Co-morbidities explained 9.1% of the variance of HSUs, 16.0% of physical super-dimensional scores, and 4.2% of psychosocial super-dimensional scores. Arthritis was associated with a significant reduction on HSUs (β =  - 0.09, 95% confidence interval [CI] - 0.16 to - 0.02), largely driven by reduced scores on the physical super-dimension (β =  - 0.13, 95% CI - 0.20 to - 0.06). Heart diseases were associated with a significant reduction on HSUs (β =  - 0.09, 95% CI - 0.16 to - 0.02), driven by reduced scores on physical (β =  - 0.09, 95% CI - 0.16 to - 0.02) and psychosocial (β = -0.10, 95% CI - 0.17 to - 0.02) super-dimensions.

conclusionsCo-morbidities significantly impact HRQoL of people with IPF, with markedly negative impacts on their HSUs and physical health. A more holistic approach to the care of people with IPF is important as better management of these co-morbidities could lead to improved HRQoL in people with IPF.

Indexed as

Idiopathic Pulmonary FibrosisQuality of LifeAustraliaHumansMorbiditySurveys and QuestionnairesAQoL-8DCo-morbidityHealth-related quality of lifeIdiopathic pulmonary fibrosisRelative contribution

Identifiers

PMID36572788
OpenAlexW4312182747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.