Evidence map›Paper›PMID 36572748›Full record

ArticleEye (London, England)2023

Real world outcomes of photodynamic therapy for chronic central serous chorioretinopathy.

Samir Khandhadia, Suresh Thulasidharan, Nguyen Thuy Vy Hoang, Sameh Alkhalili Ibrahim, Yanling Ouyang, Andrew Lotery

Abstract read
In one paragraph

Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Evaluation of choriocapillaris perfusion changes in chronic central serous chorioretinopathy following Half-Dose photodynamic therapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Article
  4. Pachychoroid disease: review and update.Eye (London, England) · 2025
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samir Khandhadia *University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Suresh Thulasidharan *University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Nguyen Thuy Vy HoangUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
Sameh Alkhalili IbrahimUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
Yanling OuyangUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
Andrew LoteryUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK. A.J.Lotery@soton.ac.uk.ORCID 0000-0001-5541-4305

Funding

Medical Research Council MC_PC_16004
6 · The paper itself

Abstract

objectivesWe describe the real-world outcomes of photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR) in a single centre over nine years.

methodsWe carried out a retrospective analysis of patients with chronic CSCR who received half dose PDT in a single centre between 2011 and 2019. Visual acuity (VA) and retinal thickness (RT) was recorded between baseline visit and first recorded review visit.

resultsWe included 125 eyes of 113 patients in this study. Mean age at treatment was 55.0 ± 12.1 years, with a higher male predominance (83 men, 30 women). Mean baseline VA was 0.40 ± 0.31 logMAR with a mean visual outcome gain post-PDT of 0.05 logMAR (p = 0.005). Mean baseline RT was 390 ± 82 microns with a mean reduction of RT post-PDT of 66 microns (p < 0.001). 17.6% of eyes were treated for recurrent CSCR.

conclusionWe found overall a mean improvement in VA and structural outcomes after PDT. In the absence of randomised clinical trials this study supports the use of half dose PDT for treatment of chronic CSCR.

Indexed as

Central Serous ChorioretinopathyPhotochemotherapyPorphyrinsAdultAgedChronic DiseaseFemaleFluorescein AngiographyHumansMaleMiddle AgedPhotosensitizing AgentsRetrospective StudiesTomography, Optical CoherenceVerteporfinPhotosensitizing AgentsPorphyrinsVerteporfin

Identifiers

PMID36572748
PMCPMC10397181

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.