ArticleScientific reports2022
Fabrication and characterization of polycaprolactone/cellulose acetate blended nanofiber mats containing sericin and fibroin for biomedical application.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Design and applications of barrier membranes for guided bone regeneration.Bioactive materials · 2026Review
- Synthesis of Click-Ready Aminooxy-Terminated Poly(ε-caprolactone) Oligomers for Oxime Ligation.Bioconjugate chemistry · 2026Article
- Shell Distribution of Vitamin K3 within Reinforced Electrospun Nanofibers for Improved Photo-Antibacterial Performance.International journal of molecular sciences · 2024Article
- Antibacterial Electrospun Membrane with Hierarchical Bead-on-String Structured Fibres for Wound Infections.Nanomaterials (Basel, Switzerland) · 2024Article
- Melatonin/Sericin Wound Healing Patches: Implications for Melanoma Therapy.International journal of molecular sciences · 2024Review
- Surface modification strategies for improved hemocompatibility of polymeric materials: a comprehensive review.RSC advances · 2024Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycaprolactone/cellulose acetate blended nanofiber mats containing sericin and fibroin were fabricated by electrospinning process to study the effect of sericin and fibroin on the physical and structural properties, wettability, degradability, elastic modulus, cell adhesion, and cell cytotoxicity of the electrospun nanofibers. Polycaprolactone/cellulose acetate solution was prepared with different percentage ratio of sericin and fibroin to be the running solution. Nanofibers were spun at fixed solution flow rate, flying distance, and operating voltage. The diameter of the obtained nanofibers linearly increases with the increasing of the sericin ratio. The derivative structures of polycaprolactone, cellulose acetate, sericin, and fibroin of the obtained nanofibers were confirmed by FTIR analysis. All acquired nanofibers show superhydrophilicity with adequate time of degradation for L-929 cell adhesion and growth. More elasticity is gained when the sericin ratio decreases. Moreover, all fibers containing sericin/fibroin reveal more elasticity, cell adhesion, and cell growth than that with only polycaprolactone/cellulose acetate. Greater cell adhesion and growth develop when the sericin ratio is lower. All the fabricated nanofibers are low toxic to the cells. Fibers with a mixture of sericin and fibroin at 2.5:2.5 (% w/v) are the most promising and suitable for further clinical development due to their good results in each examination. The novelty found in this study is not only making more value of the sericin, silk industrial waste, and the fibroin, but also getting the preferable biomaterials, scaffold prototype, with much greater mechanical property and slower degradation, which are required and appropriate for cell attachment and proliferation of cell generation process, compared to that obtaining from polycaprolactone/cellulose acetate or sericin/fibroin nanofibers.
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