ArticleMolecular biology and evolution2023
Population Genetic Considerations Regarding Evidence for Biased Mutation Rates in Arabidopsis thaliana.
Article in Molecular biology and evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Causal inference clarifies the roles of background selection and mutation rate variation in shaping human genetic diversity.bioRxiv : the preprint server for biology · 2026Article
- Amino Acid Properties, Substitution Rates, and the Nearly Neutral Theory.Genome biology and evolution · 2025Article
- Characterization and distribution of de novo mutations in the zebra finch.Communications biology · 2024Article
- Article
- Temporal challenges in detecting balancing selection from population genomic data.G3 (Bethesda, Md.) · 2024Article
- H3K4me1 recruits DNA repair proteins in plants.The Plant cell · 2024Article
- The divergence of mutation rates and spectra across the Tree of Life.EMBO reports · 2023Review
- Developmental Selection and the Perception of Mutation Bias.Molecular biology and evolution · 2023Article
- Developing an appropriate evolutionary baseline model for the study of SARS-CoV-2 patient samples.PLoS pathogens · 2023Review
- Population genetic concerns related to the interpretation of empirical outliers and the neglect of common evolutionary processes.Heredity · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
It has recently been proposed that lower mutation rates in gene bodies compared with upstream and downstream sequences in Arabidopsis thaliana are the result of an "adaptive" modification of the rate of beneficial and deleterious mutations in these functional regions. This claim was based both on analyses of mutation accumulation lines and on population genomics data. Here, we show that several questionable assumptions were used in the population genomics analyses. In particular, we demonstrate that the difference between gene bodies and less selectively constrained sequences in the magnitude of Tajima's D can in principle be explained by the presence of sites subject to purifying selection and does not require lower mutation rates in regions experiencing selective constraints.
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