ReviewNeuropharmacology2023
Expanding the canon: An inclusive neurobiology of thalamic and subthalamic fear circuits.
Review in Neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Decoding Transdiagnostic Subtypes in Emotional Disorders.CNS neuroscience & therapeutics · 2026Article
- Prefrontal-raphe-habenular circuit drives fear memory recall and updating.Nature communications · 2026Article
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Magnetic resonance microscopy maps widespread effects of Alzheimer's disease on brain structures and behavior in mice.Nature neuroscience · 2026Article
- Ensembles and engrams in mouse cortical and sub-thalamic brain regions supporting context and memory recall.Neurobiology of learning and memory · 2026Article
- Article
- Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury.Biology · 2025Review
- Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder.Biological psychiatry global open science · 2025Article
- Telomere Dynamics in Post-Traumatic Stress Disorder: A Critical Synthesis.Biomedicines · 2025Review
- Article
- Memory reconsolidation: a proposed change mechanism for the arts therapies.Frontiers in cognition · 2025Article
- Intergenerational Effects of Stress - A Focus on Learning and Memory.Current topics in behavioral neurosciences · 2025Review
- Sex Differences in the Neurobiology of Fear and Anxiety.Current topics in behavioral neurosciences · 2025Review
- Microglia contribute to mammary tumor-induced neuroinflammation in a female mouse model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination.Nature communications · 2023Article
- From recent advances in underlying neurocircuitry of fear and anxiety to promising pharmacotherapies for PTSD: The saga of heart, sex and the developing brain.Neuropharmacology · 2023Article
- Direct Thalamic Inputs to Hippocampal CA1 Transmit a Signal That Suppresses Ongoing Contextual Fear Memory Retrieval.Research square · 2023Article
- Direct Thalamic Inputs to Hippocampal CA1 Transmit a Signal That Suppresses Ongoing Contextual Fear Memory Retrieval.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Appropriate expression of fear in the face of threats in the environment is essential for survival. The sustained expression of fear in the absence of threat signals is a central pathological feature of trauma- and anxiety-related disorders. Our understanding of the neural circuitry that controls fear inhibition coalesces around the amygdala, hippocampus, and prefrontal cortex. By discussing thalamic and sub-thalamic influences on fear-related learning and expression in this review, we suggest a more inclusive neurobiological framework that expands our canonical view of fear. First, we visit how fear-related learning and expression is influenced by the aforementioned canonical brain regions. Next, we review emerging data that shed light on new roles for thalamic and subthalamic nuclei in fear-related learning and expression. Then, we highlight how these neuroanatomical hubs can modulate fear via integration of sensory and salient stimuli, gating information flow and calibrating behavioral responses, as well as maintaining and updating memory representations. Finally, we propose that the presence of this thalamic and sub-thalamic neuroanatomy in parallel with the tripartite prefrontal cortex-amygdala-hippocampus circuit allows for dynamic modulation of information based on interoceptive and exteroceptive signals. This article is part of the Special Issue on "Fear, Anxiety and PTSD".
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.