Evidence map›Paper›PMID 36572136›Full record

ArticleClinica chimica acta; international journal of clinical chemistry2023

Evaluating the value of anti-SARS-CoV-2 antibody detection and neutralizing responses with euvirus: A population of 10776 close contacts in the epidemic of Fujian.

Yongbin Zeng, Caorui Lin, Can Liu, Chun Huang, Falin Chen, Yingping Cao, Siying Wu, Donghong Wei, Zhong Lin, Yali Zhang and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinica chimica acta; international journal of clinical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 1 country.

Yongbin ZengDepartment of Laboratory Medicine, Gene Diagnosis Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China; Fujian Key Laboratory of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China.
Caorui LinDepartment of Laboratory Medicine, Gene Diagnosis Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China; Fujian Key Laboratory of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China.
Can LiuDepartment of Laboratory Medicine, Gene Diagnosis Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China; Fujian Key Laboratory of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China.
Chun HuangFujian Medical Association, Fuzhou, PR China.
Falin ChenDepartment of Clinical Laboratory, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, PR China.
Yingping CaoDepartment of Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou, PR China.
Siying WuDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, PR China.
Donghong WeiDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, PR China.
Zhong LinFujian Provincial Center for Disease Control and Prevention, Fuzhou, PR China.
Yali ZhangThe State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health and School of Life Science, Xiamen University, Xiamen, PR China.
Ling ZhangDepartment of Laboratory Medicine, Land Force No.73 Group Army Hospital of PLA, Xiamen, PR China.
Jing TengDepartment of Laboratory Medicine, Beijing University of Chinese Medicine Xiamen Hospital, Xiamen, PR China.
Zishun LiDepartment of Laboratory Medicine, The Third Hospital of Xiamen, Xiamen, PR China.
Guolin HongDepartment of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Genetic Testing, School of Medicine, Xiamen University, Xiamen, PR China.
Tianci YangCenter of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, PR China.
Huiming YeDepartment of Clinical Laboratory, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, PR China.
Haijian TuDepartment of Laboratory Medicine, Affiliated Hospital of Putian University, Putian, PR China.
Yupeng XiaoDepartment of Clinical Laboratory, Putian Municipal First Hospital, Putian, PR China.
Lishan HuangFujian Provincial Healthcare Center, Fuzhou, PR China.
Jiawei ZhangDepartment of Laboratory Medicine, Gene Diagnosis Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China; Fujian Key Laboratory of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China.
Tianbin ChenDepartment of Laboratory Medicine, Gene Diagnosis Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China; Fujian Key Laboratory of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China.
Jinming LiNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, PR China. Electronic address: jmli@nccl.org.cn.
Fusui JiBeijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science, PR China. Electronic address: jifusui0367@bjhmoh.cn.
Qishui OuDepartment of Laboratory Medicine, Gene Diagnosis Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China; Fujian Key Laboratory of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China. Electronic address: ouqishui@fjmu.edu.cn.
Fujian Medical University · CNFirst Affiliated Hospital of Fujian Medical University · CNPutian University · CNXiamen University · CN174th hospital of the People's Liberation Army · CNBeijing University of Chinese Medicine · CNFirst Affiliated Hospital of Xiamen University · CNFujian Provincial Hospital · CNGansu Provincial Center for Disease Control and Prevention · CNThird Hospital of Changsha · CNZhongshan Hospital of Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNucleic acid detection represents limitations due to its false-negative rate and technical complexity in the COVID-19 pandemic. Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody tests are widely spread all over the world presently. However, there is no report on the effectiveness of anti-SARS-CoV-2 antibody testing methods in China.

methodsWe gathered 10776 serum samples from close contacts of the SARS-CoV-2 infections in Fujian of China and used 2 chemiluminescence immunoassays (Wantai Bio., Yahuilong Bio.) and 2 lateral flow immunoassays (Lizhu Bio. and Dongfang Bio.) to perform the anti-SARS-CoV-2 antibody tests in China.

resultsThe 4 antibody tests have great diagnostic value for infected or uninfected, especially in the neutralizing antibodies tests, the AUC can reach 0.939 (Wantai Bio.) and 0.916 (Yahuilong Bio.). Furthermore, we used pseudoviruses and euvirus neutralization assay to validate the effectiveness of these antibody test, the results of pseudoviruses neutralization assay or euvirus neutralization assay shows a considerable correlation with the 4 antibody detection respectively, particularly in euvirus neutralization assay, neutralizing antibodies detected by Wantai Bio. or Yahuilong Bio., the correlation can get the level of 0.93 or 0.82.

conclusionsThe findings of this study demonstrate that the detections of antibodies have profound value in the diagnosis of COVID-19.

Indexed as

COVID-19Antibodies, NeutralizingAntibodies, ViralHumansPandemicsSARS-CoV-2Antibodies, NeutralizingAntibodies, ViralAntibody testChemiluminescence immunoassaysCOVID-19Euvirus neutralization assayLateral flow immunoassaysPseudoviruses neutralization assaySARS-CoV-2

Identifiers

PMID36572136
PMCPMC9783188
OpenAlexW4313255083

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.