Evidence map›Paper›PMID 36571699›Full record

ArticleAdvances in experimental medicine and biology2023

Sounding a New Era in Biomechanics with Acoustic Force Spectroscopy.

Giulia Silvani, Valentin Romanov, Boris Martinac

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Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giulia Silvani *School of Material Science and Engineering, University of New South Wales, Sydney, NSW, Australia.
Valentin Romanov *Victor Chang Cardiac Research Institute, Lowy Packer Building, Darlinghurst, NSW, Australia.
Boris MartinacVictor Chang Cardiac Research Institute, Lowy Packer Building, Darlinghurst, NSW, Australia. b.martinac@victorchang.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The acoustic force spectroscopy (AFS) tool was recently introduced as a novel tool for probing mechanical properties of biomolecules, expanding the application of sound waves to high-throughput quantification of the mechanical properties of single cells. By using controlled acoustic forces in the piconewton to nanonewton range, tens to hundreds of cells functionalized by attached microspheres can simultaneously be stretched and tracked in real-time with sub millisecond time response. Since its first application, several studies have demonstrated the potential and versatility of the AFS for high-throughput measurements of force-induced molecular mechanisms, revealing insight into cellular biomechanics and mechanobiology at the molecular level. In this chapter, we describe the operation of the AFS starting with the underlying physical principles, followed by a run-down of experimental considerations, and finally leading to applications in molecular and cellular biology.

Indexed as

AcousticsMechanical PhenomenaBiomechanical PhenomenaSoundSpectrum AnalysisAcoustic force spectroscopy (AFS)Acoustic radiation forceAcoustic standing wavesAdhesion kineticsAdhesion strengthBiomechanicsLab-on-a-chipMechanobiologyMicrofluidicSingle biomoleculeViscoelasticity

Identifiers

PMID36571699

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.