Evidence map›Paper›PMID 36571695›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2023

New update to the guidelines on testing predictive biomarkers in non-small-cell lung cancer: a National Consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology.

Dolores Isla, Maria D Lozano, Luis Paz-Ares, Clara Salas, Javier de Castro, Esther Conde, Enriqueta Felip, Javier Gómez-Román, Pilar Garrido, Ana Belén Enguita

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Recommendations for diagnosis and management of non-small-cell lung carcinoma patients with ex20ins EGFR mutations: insights from a Delphi consensus.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  7. Review
  8. Monitoring of the oncological process for lung cancer in Spain: an expert consensus report.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  9. Article
  10. Prevalence ofTranslational lung cancer research · 2025
    Article
  11. Article
  12. Article
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  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. The Impact of Liquid Biopsies Positive forDiagnostics (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Dolores IslaLozano Blesa University Clinical Hospital, IIS Aragón, Spanish Society of Medical Oncology (SEOM), C. de San Juan Bosco, 15, 50009, Zaragoza, Spain. lola.isla@gmail.com.ORCID http://orcid.org/0000-0002-2483-198X
Maria D LozanoClínica Universidad de Navarra, Spanish Society of Cytology (SEC), Spanish Society of Pathology (SEAP), Pamplona, Spain.
Luis Paz-Ares12 de Octubre University Hospital, Spanish Society of Medical Oncology (SEOM), Madrid, Spain.
Clara SalasPuerta de Hierro University Hospital, Spanish Society of Pathology (SEAP), Madrid, Spain.
Javier de CastroLa Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ), Spanish Society of Medical Oncology (SEOM), Madrid, Spain.
Esther Conde12 de Octubre University Hospital, Research Institute 12 de Octubre University Hospital (I+12), Spanish Society of Pathology (SEAP), Madrid, Spain.
Enriqueta FelipVall d'Hebron University Hospital, Spanish Society of Medical Oncology (SEOM), Barcelona, Spain.
Javier Gómez-RománCantabria University, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute (IDIVAL), Spanish Society of Pathology (SEAP), Santander, Spain.
Pilar GarridoRamón y Cajal University Hospital, Spanish Society of Medical Oncology (SEOM), Madrid, Spain.
Ana Belén Enguita12 de Octubre University Hospital, Spanish Society of Pathology (SEAP), Madrid, Spain.
Spanish Society of Hematology and Hemotherapy · ESClinica Universidad de Navarra · ESHospital Clínico Universitario Lozano Blesa · ESHospital La Paz Institute for Health Research · ESMarqués de Valdecilla University Hospital · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) presents the greatest number of identified therapeutic targets, some of which have therapeutic utility. Currently, detecting EGFR, BRAF, KRAS and MET mutations, ALK, ROS1, NTRK and RET translocations, and PD-L1 expression in these patients is considered essential. The use of next-generation sequencing facilitates precise molecular diagnosis and allows the detection of other emerging mutations, such as the HER2 mutation and predictive biomarkers for immunotherapy responses. In this consensus, a group of experts in the diagnosis and treatment of NSCLC selected by the Spanish Society of Pathology and the Spanish Society of Medical Oncology have evaluated currently available information and propose a series of recommendations to optimize the detection and use of biomarkers in daily clinical practice.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsBiomarkers, TumorConsensusHumansMedical OncologyMutationProtein-Tyrosine KinasesProto-Oncogene ProteinsBiomarkers, TumorProtein-Tyrosine KinasesProto-Oncogene ProteinsALKBiomarkersBRAFEGFRNon-small cell lung cancerPD-L1ROS1

Identifiers

PMID36571695
PMCPMC10119050
OpenAlexW4312195879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.