Evidence map›Paper›PMID 36571613›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023

Olfaction in nasal polyp patients after Reboot surgery: an endotype-based prospective study.

Sara Costa Gomes, Tim Delemarre, Gabriele Holtappels, Thibaut Van Zele, Lara Derycke, Ellen Bonne, Anne-Sophie Eeckels, Nan Zhang, Richard Louis Voegels, Claus Bachert

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. [Research progress on the improvement of olfactory function by different surgical procedures for chronic rhinosinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Sara Costa GomesOtorhinolaryngology and Ophthalmology Department, Faculty of Medicine, University of Sao Paulo (USP), Sao Paulo, Brazil.ORCID http://orcid.org/0000-0001-6357-2047
Tim DelemarreUpper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, 1P1 UZ Gent, MRB2. Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Gabriele HoltappelsUpper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, 1P1 UZ Gent, MRB2. Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Thibaut Van ZeleUpper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, 1P1 UZ Gent, MRB2. Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Lara DeryckeUpper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, 1P1 UZ Gent, MRB2. Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Ellen BonneUpper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, 1P1 UZ Gent, MRB2. Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Anne-Sophie EeckelsUpper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, 1P1 UZ Gent, MRB2. Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Nan ZhangUpper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, 1P1 UZ Gent, MRB2. Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Richard Louis VoegelsOtorhinolaryngology and Ophthalmology Department, Faculty of Medicine, University of Sao Paulo (USP), Sao Paulo, Brazil.
Claus BachertUpper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, 1P1 UZ Gent, MRB2. Corneel Heymanslaan 10, 9000, Ghent, Belgium. claus.bachert@ugent.be.ORCID http://orcid.org/0000-0003-4742-1665
Ghent University Hospital · BEUniversidade de São Paulo · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 6685 - PRINT - Institutional program of internationalizationCoordenação de Aperfeiçoamento de Pessoal de Nível Superior file 88887.570290/2020-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Financial code 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior nº 41/2017. CAPES DS 88887.687165/2022-00.
6 · The paper itself

Abstract

purposeTo report biomarkers present in the olfactory mucosa in chronic rhinosinusitis with nasal polyps (CRSwNP) in comparison with nasal polyps and to nasal mucosal tissues from control patients. To evaluate the kinetics of smell over 6 months in patients who underwent Reboot surgery.

methodsCohort study from May 2021 to May 2022. We collected samples of olfactory mucosa and nasal polyps from 16 CRSwNP patients and inferior turbinate samples from 20 control subjects. The study was not randomized for surgical and/or medical treatment. Samples were analyzed by Luminex and Unicap 100 to measure biomarkers of inflammation (IL1-β, IL4, IL5, IL6, IL17, CCL3, CCL4, G-CSF, SE-IgE, total IgE and ECP). 12 of the CRSwNP patients underwent Extended Sniffin'tests at timepoints 1-4 days pre-surgery, and 1, 3 and 6 months after Reboot surgery.

resultsType-2 markers were significantly elevated in OM and polyp tissue in CRSwNP (n = 16) vs. controls (n = 20), P < 0.05. TDI scores improved already 1 month (P < 0.05) after surgery and remained stable for 6 months. Type-2 inflammation in nasal polyps was associated with decreased sense of smell and taste before surgery, but improved after surgery (P = 0.048). Type-3 inflammation was present in the olfactory mucosa and was associated with a better sense of smell before surgery, but a smaller improvement of smell afterward.

conclusionsType-2 inflammation is present in the olfactory mucosa in CRSwNP patients and is associated with smell loss. Reboot surgery, aiming to completely remove inflamed sinus mucosa, significantly improves the smell in this group of patients.

Indexed as

Nasal PolypsOlfaction DisordersRhinitisSinusitisChronic DiseaseCohort StudiesHumansImmunoglobulin EInflammationProspective StudiesSmellImmunoglobulin EAnosmiaNasal polypsNasal surgical proceduresOlfaction disordersSinusitisSmell

Identifiers

PMID36571613
PMCPMC9791624
OpenAlexW4312222613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.