Evidence map›Paper›PMID 36571449›Full record

ArticleCancer science2023

Single-cell next-generation sequencing of circulating tumor cells in patients with neuroblastoma.

Masato Kojima, Takanori Harada, Takahiro Fukazawa, Sho Kurihara, Ryo Touge, Isamu Saeki, Shinya Takahashi, Eiso Hiyama

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Masato KojimaDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID https://orcid.org/0000-0001-7783-0289
Takanori HaradaNatural Science Center for Basic Research and Development (N-BARD), Hiroshima University, Hiroshima, Japan.
Takahiro FukazawaNatural Science Center for Basic Research and Development (N-BARD), Hiroshima University, Hiroshima, Japan.
Sho KuriharaDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Ryo TougeDepartment of Pediatric Surgery, Hiroshima University Hospital, Hiroshima, Japan.
Isamu SaekiDepartment of Pediatric Surgery, Hiroshima University Hospital, Hiroshima, Japan.
Shinya TakahashiDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Eiso HiyamaDepartment of Pediatric Surgery, Hiroshima University Hospital, Hiroshima, Japan.ORCID https://orcid.org/0000-0001-9179-5037
Hiroshima University · JPHiroshima University Hospital · JP

Funding

Japan Agency for Medical Research and Development JP22ama221403Japan Agency for Medical Research and Development JP22ck0106609Japan Society for the Promotion of Science Kakenhi JP20K08927Japan Society for the Promotion of Science Kakenhi JP22H031315Japan Society for the Promotion of Science Kakenhi JP22KK013
6 · The paper itself

Abstract

Circulating tumor cells (CTCs) derived from any tumor tissue could contribute to metastasis and resistance to cancer treatments. In this study, we performed single-cell next-generation sequencing of CTCs and evaluated their usefulness for characterizing tumor biology and the mechanisms of metastasis in neuroblastomas (NB). We aimed to isolate CTCs from 10 patients with NB at diagnosis before any treatments and four patients at relapse. GD2

Indexed as

Neoplastic Cells, CirculatingNeuroblastomaBiomarkers, TumorHigh-Throughput Nucleotide SequencingHumansMutationNeoplasm Recurrence, LocalBiomarkers, Tumorcirculating tumor cellsliquid biopsyneuroblastomanext-generation sequencingsingle-cell sequencing

Identifiers

PMID36571449
PMCPMC10067419
OpenAlexW4312195507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.