Evidence map›Paper›PMID 36570973›Full record

ArticleThe Lancet regional health. Southeast Asia2023

Characteristics and One Year Outcomes of Melioidosis Patients in Northeastern Thailand: A Prospective, Multicenter Cohort Study.

Narisara Chantratita, Rungnapa Phunpang, Atchara Yarasai, Adul Dulsuk, Thatcha Yimthin, Lauren A Onofrey, Taylor D Coston, Ekkachai Thiansukhon, Seksan Chaisuksant, Kittisak Tanwisaid and 10 more

Abstract read
In one paragraph

Article in The Lancet regional health. Southeast Asia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Narisara ChantratitaDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Rungnapa PhunpangDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Atchara YarasaiDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Adul DulsukDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Thatcha YimthinDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Lauren A OnofreyDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
Taylor D CostonDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
Ekkachai ThiansukhonDepartment of Medicine, Udon Thani Hospital, Udon Thani, Thailand.
Seksan ChaisuksantDepartment of Medicine, Khon Kaen Regional Hospital, Khon Kaen, Thailand.
Kittisak TanwisaidDepartment of Medicine, Nakhon Phanom Hospital, Nakhon Phanom, Thailand.
Somchai ChuananontDepartment of Medicine, Nakhon Phanom Hospital, Nakhon Phanom, Thailand.
Chumpol MorakotDepartment of Medicine, Mukdahan Hospital, Mukdahan, Thailand.
Narongchai SangsaDepartment of Medicine, Roi Et Hospital, Roi Et, Thailand.
Sunee ChayangsuDepartment of Medicine, Surin Hospital, Surin, Thailand.
Wirayut SilakunDepartment of Medicine, Buriram Hospital, Buriram, Thailand.
Noppol BuasiDepartment of Medicine, Sisaket Hospital, Sisaket, Thailand.
Ploenchan ChetchotisakdDepartment of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.
Nicholas Pj DayMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Ganjana LertmemongkolchaiDepartment of Medical Technology, Faculty of Associated Medical Science, Chiang Mai University, Chiang Mai, Thailand.
T Eoin WestDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Funding

Determinants of Outcome and Recurrent Infections in MelioidosisU01AI115520 · NIAID · MAHIDOL UNIVERSITY · PI CHANTRATITA, NARISARA, WEST, TIMOTHY EOIN · 2015 to 2019
$2.0M
NIAID NIH HHS U01 AI115520
6 · The paper itself

Abstract

Background: Melioidosis is a neglected tropical infection caused by the environmental saprophyte Methods: We conducted a prospective, observational study at nine hospitals in northeastern Thailand, a hyperendemic melioidosis zone, to define current characteristics of melioidosis patients and quantify outcomes over one year. Findings: 2574 individuals hospitalised with culture-confirmed melioidosis were screened and 1352 patients were analysed. The median age was 55 years, 975 (72%) were male, and 951 (70%) had diabetes. 565 (42%) patients presented with lung infection, 1042 (77%) were bacteremic, 442 (33%) received vasopressors/inotropes and 547 (40%) received mechanical ventilation. 1307 (97%) received an intravenous antibiotic against Interpretation: In northeastern Thailand patients with melioidosis experience high rates of bacteremia, organ failure and death. Most patients discharged alive survive one year although all-cause readmission is common. Recurrent disease is rare. Strategies that emphasize prevention, rapid diagnosis and intensification of early clinical management are likely to have greatest impact in this and other resource-restricted regions. Funding: US NIH/NIAID U01AI115520.

Identifiers

PMID36570973
PMCPMC9788505

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.