ReviewFrontiers in neuroscience2022
Therapeutic approaches for improving cognitive function in the aging brain.
Review in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of mind-body health qigong exercise on depression severity and cognitive function in older adults at a senior care center: a randomized controlled trial.Frontiers in public health · 2026Trial
- The Exercise-CTSS-AD Axis: a novel framework for understanding exercise-induced neuroprotection in Alzheimer's disease.Metabolic brain disease · 2026Review
- Why some minds bend, not break: an exploratory study of cognitive and psychological performance across levels of cognitive reserve in subjective cognitive decline.Frontiers in psychology · 2026Article
- Cerebrolysin Ameliorates Age-Induced Dendritic Spine Degeneration and Memory Decline in C57BL6 Mice.Neurochemical research · 2025Article
- Water extract ofMolecular medicine reports · 2025Article
- Effects of Dance-Based Aerobic Training on Frailty and Cognitive Function in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial.Diagnostics (Basel, Switzerland) · 2025Article
- Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024.F1000Research · 2025Article
- Development of a submicron emulsion-based delivery system to improve the anti-inflammatory activity of urolithin A.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2025Article
- Evaluating the Effectiveness of Cognitive Interventions for Healthy and Mild Cognitive Impairment Adults: A Comprehensive Umbrella Meta-Analysis.Journal of aging research · 2025Review
- Obesity and its associations with autonomic and cognitive functions in the general population.PloS one · 2025Article
- N-Pep-Zn Improves Cognitive Functions and Acute Stress Response Affected by Chronic Social Isolation in Aged Spontaneously Hypertensive Rats (SHRs).Biomedicines · 2024Article
- Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity.Journal of the American College of Cardiology · 2024Article
- Comment on Krikorian et al. Early Intervention in Cognitive Aging with Strawberry Supplementation.Nutrients · 2024Article
- Heart Rate Variability and Cognition: A Narrative Systematic Review of Longitudinal Studies.Journal of clinical medicine · 2024Review
- Harnessing Passive Pulsatile Shear Stress for Alzheimer's Disease Prevention and Intervention.Journal of Alzheimer's disease : JAD · 2024Review
- Exploring the interplay between running exercises, microbial diversity, and tryptophan metabolism along the microbiota-gut-brain axis.Frontiers in microbiology · 2024Article
- Review
- Molecular Mechanisms for the Carnosine-Induced Activation of Muscle-Brain Interaction.Nutrients · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapid aging of populations around the world has become an unprecedented challenge. Aging is associated with cognitive impairment, including dementia and mild cognitive impairment. Successful drug development for improving or maintaining cognition in the elderly is critically important. Although 4 drugs for improving cognition in Alzheimer's disease have been approved, a variety of potential drugs targeting age-related cognitive impairment are still in development. In addition, non-pharmacological interventions, including cognition-oriented treatments, non-invasive brain stimulation physical exercise, and lifestyle-related interventions, have also been suggested as cognitive enhancers in the last decade. In this paper, we reviewed the recent evidence of pharmacological and non-pharmacological interventions aimed at improving or maintaining cognition in the elderly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.