Evidence map›Paper›PMID 36570594›Full record

ArticleInterdisciplinary perspectives on infectious diseases2022

The Presence of Antineutrophil Cytoplasmic Antibodies and Antiphospholipid Antibodies in Patients with Severe Acute Respiratory Syndrome Coronavirus 2: A Case-Control Study among Sudanese Patients.

Mohammed Shams Aldeen, Musa Logman Masaad, Ayman Azhary, Abdulomez Suliman, Mohammed Ahmed Alziber, Motasim MohammedAhmed, Farag Alla Mohamed Aman, Salahaldeen Ismail, Nadir Abuzeid, Abdualmoniem O Musa and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interdisciplinary perspectives on infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Mohammed Shams AldeenDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.ORCID https://orcid.org/0000-0003-2170-7059
Musa Logman MasaadDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.ORCID https://orcid.org/0000-0002-2011-7260
Ayman AzharyDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.ORCID https://orcid.org/0000-0002-2804-1408
Abdulomez SulimanDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.
Mohammed Ahmed AlziberDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.
Motasim MohammedAhmedDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.ORCID https://orcid.org/0000-0002-5105-7491
Farag Alla Mohamed AmanDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.
Salahaldeen IsmailDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.ORCID https://orcid.org/0000-0001-9991-1573
Nadir AbuzeidDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.ORCID https://orcid.org/0000-0003-2074-7892
Abdualmoniem O MusaDepartment of Medical Microbiology, Faculty of Medicine and Health Sciences, Kassala University, Kassala, Sudan.ORCID https://orcid.org/0000-0002-3712-9612
Samuel Tekle MengistuNakfa Hospital, North Red Sea Branch of the Ministry of Health, Nakfa, Eritrea.ORCID https://orcid.org/0000-0002-2817-1421
Mohammed Elfatih HamidaDepartment of Medical Microbiology, Orotta College of Medicine and Health Sciences, Asmara, Eritrea.ORCID https://orcid.org/0000-0002-5337-399X
Omdurman Islamic University · SDKassala University · SDMinisterio de Salud · SVUniversity of Asmara · ER

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients infected with COVID-19 are at an increased risk for thrombosis, suggesting a possible role of COVID-19 in the induction of coagulopathy. This study aimed to investigate the presence of prothrombotic antineutrophil cytoplasmic antibodies (ANCA) and antiphospholipid antibodies (aPLs) in the course of COVID-19 infection and to correlate these markers with severity and fatality, suggesting that COVID-19-induced autoimmune thrombosis is a possible axis in the inflammatory circuit of this infection. To investigate this, we conducted a case-control study which included patients with a positive reverse transcription-polymerase chain reaction (RT-PCR) test of COVID-19 and a control group with negative COVID-19 PCR and antibody (IgG-IgM and IgA nucleoprotein) ELISA results. An indirect immunofluorescence assay using granulocyte biochips (Aesku slides from AESKU DIAGNOSTICS, Germany) was used to detect ANCA (IgG), as well as multiplex ELISA for the detection of antiphospholipid antibodies for all patients with COVID-19 and for the control group. The results revealed the detection of antiphospholipid antibodies (IgG) in one patient out of the 45 patients in the case group. 1/45(2.2%) and 7/45(15.6%) tested positive for ANCA. Five were men and two were females, with one case revealed to be positive for both aPL and ANCA. A cytoplasmic reaction on the eosinophil granulocytes was observed in 2 cases; both were positive for ANCA. Other markers (CRP, APTT, PT, INR, ESR, and neutrophil and lymphocyte counts) were included in the study, along with demographic data. No aPL or ANCA reactions were detected for any of the control groups. These findings suggest that aPL and ANCA may be induced during the course of inflammation in COVID-19 and possibly contribute to the disease's severity and mortality.

Identifiers

PMID36570594
PMCPMC9780010
OpenAlexW4311552328

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.