Evidence map›Paper›PMID 36570474›Full record

ArticleACS applied nano materials2022

Five-Minute Magnetic Nanoparticle Spectroscopy-Based Bioassay for Ultrafast Detection of SARS-CoV-2 Spike Protein.

Kai Wu, Vinit Kumar Chugh, Venkatramana D Krishna, Yongqiang Andrew Wang, Timothy D Gordon, Maxim C-J Cheeran, Jian-Ping Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied nano materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kai WuDepartment of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Vinit Kumar ChughDepartment of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Venkatramana D KrishnaDepartment of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota 55108, United States.
Yongqiang Andrew WangOcean Nano Tech LLC, San Diego, California 92126, United States.
Timothy D GordonAerosol Devices Inc., Fort Collins, Colorado 80524, United States.
Maxim C-J CheeranDepartment of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota 55108, United States.
Jian-Ping WangDepartment of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Funding

A SARS-CoV-2 Breathalyzer for Direct Virus DetectionR42DE030832 · NIDCR · AEROSOL DEVICES, INC. · PI KEADY, PATRICIA BEA · 2021 to 2021
$254k
NIDCR NIH HHS R42 DE030832
6 · The paper itself

Abstract

In this work, we report a 5-min magnetic particle spectroscopy (MPS)-based bioassay strategy. In our approach, surface-functionalized magnetic nanoparticles are incubated with target analytes at 37 °C with agitation for 3 min, and the MPS reading is then taken at the fifth minute. We prove the feasibility of 5 min ultrafast detection of SARS-CoV-2 spike protein with a detection limit below 5 nM (0.2 pmol). Our proposed 5-min bioassay strategy may be applied to reduce the assay time for other liquid-phase, volumetric biosensors such as NMR, quantum dots, fluorescent biosensors, etc.

Identifiers

PMID36570474
PMCPMC9762417

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.