Evidence map›Paper›PMID 36570470›Full record

ArticleACS measurement science au2022

Electrochemical Capillary Driven Immunoassay for Detection of SARS-CoV-2.

Kaylee M Clark, Melissa S Schenkel, Trey W Pittman, Isabelle C Samper, Loran B R Anderson, Wisarut Khamcharoen, Suad Elmegerhi, Rushika Perera, Weena Siangproh, Alan J Kennan and 3 more

Open access · goldAbstract read
In one paragraph

Article in ACS measurement science au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Kaylee M ClarkDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Melissa S SchenkelDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Trey W PittmanDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Isabelle C SamperDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Loran B R AndersonDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, United States.
Wisarut KhamcharoenDepartment of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.
Suad ElmegerhiDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, United States.
Rushika PereraDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, United States.ORCID https://orcid.org/0000-0001-6798-2537
Weena SiangprohDepartment of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.
Alan J KennanDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Brian J GeissDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, United States.
David S DandyDepartment of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado 80523, United States.
Charles S HenryDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.ORCID https://orcid.org/0000-0002-8671-7728
Colorado State University · USSrinakharinwirot University · TH

Funding

A SARS-CoV-2 NFC ePAD BiosensorR01EB031510 · NIBIB · COLORADO STATE UNIVERSITY · PI DANDY, DAVID S, GEISS, BRIAN · 2021 to 2022
$1.0M
NIBIB NIH HHS R01 EB031510
6 · The paper itself

Abstract

The COVID-19 pandemic focused attention on a pressing need for fast, accurate, and low-cost diagnostic tests. This work presents an electrochemical capillary driven immunoassay (eCaDI) developed to detect SARS-CoV-2 nucleocapsid (N) protein. The low-cost flow device is made of polyethylene terephthalate (PET) and adhesive films. Upon addition of a sample, reagents and washes are sequentially delivered to an integrated screen-printed carbon electrode for detection, thus automating a full sandwich immunoassay with a single end-user step. The modified electrodes are sensitive and selective for SARS-CoV-2 N protein and stable for over 7 weeks. The eCaDI was tested with influenza A and Sindbis virus and proved to be selective. The eCaDI was also successfully applied to detect nine different SARS-CoV-2 variants, including Omicron.

Identifiers

PMID36570470
PMCPMC9469961
OpenAlexW4293581944

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.