Evidence map›Paper›PMID 36570439›Full record

ArticleFrontiers in neurology2022

Adhesion molecules and cerebral microvascular hemodynamic abnormalities in sickle cell disease.

Noor Mary Abi Rached, Oluwabukola T Gbotosho, David R Archer, Jayre A Jones, Morgan S Sterling, Hyacinth I Hyacinth

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Noor Mary Abi RachedNeuroscience and Behavioral Biology Undergraduate Program, Emory University, Atlanta, GA, United States.
Oluwabukola T GbotoshoDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
David R ArcherAflac Cancer and Blood Disorders Center, Emory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, GA, United States.
Jayre A JonesAflac Cancer and Blood Disorders Center, Emory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, GA, United States.
Morgan S SterlingAflac Cancer and Blood Disorders Center, Emory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, GA, United States.
Hyacinth I HyacinthDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Aflac (United States) · USUniversity of Cincinnati Medical Center · USEmory University · US

Funding

Mechanism of cerebral vaculopathy and stroke in sickle cell diseaseR01HL138423 · NHLBI · UNIVERSITY OF CINCINNATI · PI HYACINTH, HYACINTH IDU · 2017 to 2021
$2.5M
NHLBI NIH HHS R01 HL138423NIMHD NIH HHS L60 MD013112
6 · The paper itself

Abstract

Cerebrovascular abnormalities are a common feature of sickle cell disease that may be associated with risk of vaso-occlusive pain crises, microinfarcts, and cognitive impairment. An activated endothelium and adhesion factors, VCAM-1 and P-selectin, are implicated in sickle cell vasculopathy, including abnormal hemodynamics and leukocyte adherence. This study examined the association between cerebral expression of these adhesion factors and cortical microvascular blood flow dynamics by using

Indexed as

adhesion moleculescerebral microinfarctmicrovascular hemodynamicssickle cell diseasetwo-photon microscope

Identifiers

PMID36570439
PMCPMC9767957
OpenAlexW4311847609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.