Evidence map›Paper›PMID 36570418›Full record

ArticlePhytomedicine plus : international journal of phytotherapy and phytopharmacology2023

A randomized controlled pilot study of add-on therapy of CIM-MEG19 (standardized

Karuna Shanker, Hrishikesh Rangnekar, Asmita Wele, Pravin Soni, Pranesh Gaikwad, Anirban Pal, Dnyaneshwar U Bawankule, Debabrata Chanda

Open access · goldAbstract read
In one paragraph

Article in Phytomedicine plus : international journal of phytotherapy and phytopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Exploring the clinical effects ofFrontiers in pharmacology · 2025
    Pooled it
  2. Review
  3. Genetic analysis of seed germination rates inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025
    Article
  4. Review
  5. Article
  6. Efficacy of Kan JangPharmaceuticals (Basel, Switzerland) · 2023
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Karuna ShankerAnalytical Chemistry, Phytochemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow-226015, India.
Hrishikesh RangnekarQuestt Clinicals and Ayurceuticals, Pune, India.
Asmita WeleDepartment of Rasashastra and Bhaishajyakalpana, College of Ayurved, Bharati Vidyapeeth (Deemed to be University), Pune-411043, India.
Pravin SoniPimpri Chinchwad Municipal Corporation's Postgraduate Institute, Yashwantrao Chavan Memorial Hospital, Pimpri, Pune-411018, India.
Pranesh GaikwadPanchakarma Department, Dr. D. Y. Patil College of Ayurved and Research Centre, Dr. D. Y. Patil Vidyapeeth Pune (Deemed to be University), Pimpri, Pune-411018, India.
Anirban PalBio-Prospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015, India.
Dnyaneshwar U BawankuleAnalytical Chemistry, Phytochemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow-226015, India.
Debabrata ChandaBio-Prospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015, India.
Central Institute of Medicinal and Aromatic Plants · INBharati Vidyapeeth Deemed University · INDr. D.Y. Patil Vidyapeeth, Pune · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Traditional knowledge and scientific shreds of evidence strongly support the repurpose of Kalmegh ( Purpose: The study aimed to assess the efficacy and safety of the CIM-MEG19 (standardized Methods: A randomized, parallel-group, active-controlled interventional pilot clinical study was conducted. The Group-A subjects were assigned to CIM-MEG19 add-on to SoC treatment using modern medicine without antiviral drug whereas Group-B patients with SoC treatment using modern medicine and recommended antiviral drug for COVID-19 management. Eighty RTPCR (real-time polymerase chain reaction) positive and eligible COVID-19 patients of age >18 years, having mild or moderate severity, were enrolled. Results: Clinical improvement in reduction of symptoms showed significant ( Conclusions: The study demonstrated an excellent safety profile, declining the severity of the infection and halting the disease advancement/progression. CIM-Meg19 might be used as a potential natural drug for treating COVID-19.

Indexed as

AntiviralAyurvedic pharmacopeia of IndiaImmunomodulationInflammationKalmeghSARS-CoV-2

Identifiers

PMID36570418
PMCPMC9762910
OpenAlexW4312054361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.