Evidence map›Paper›PMID 36570248›Full record

ArticleACS omega2022

Synthesis, Characterization, DFT Mechanistic Study, Antimicrobial Activity, Molecular Modeling, and ADMET Properties of Novel Pyrazole-isoxazoline Hybrids.

Mohammed Chalkha, Hassan Nour, Khalid Chebbac, Asmae Nakkabi, Lahoucine Bahsis, Mohamed Bakhouch, Mohamed Akhazzane, Mohamed Bourass, Samir Chtita, Yousef A Bin Jardan and 4 more

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 55 citations in OpenAlex.

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  9. A Review of the Medicinal Importance and Perspectives of the 2-isoxazoline Scaffold.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Review
  10. Article
  11. Article
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  13. Article
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  15. Article
  16. Article
  17. Article
  18. Design, Synthesis and Evaluation of Antifungal Activity of Pyrazoleacetamide Derivatives.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024
    Article
  19. 3-[International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Mohammed ChalkhaEngineering Laboratory of Organometallic, Molecular, Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, 30000 Fez, Morocco.
Hassan NourLaboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, P.O. Box 7955, Casablanca, Morocco.
Khalid ChebbacLaboratory of Biotechnology Conservation and Valorisation of Natural Resources, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdallah University, P.O. Box 1796, Fez 30000, Morocco.
Asmae NakkabiEngineering Laboratory of Organometallic, Molecular, Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, 30000 Fez, Morocco.
Lahoucine BahsisLaboratory of Analytical and Molecular Chemistry, Polydisciplinary Faculty, Cadi Ayyad University, P.O. Box 4162, Safi 46000, Morocco.ORCID https://orcid.org/0000-0002-7252-6680
Mohamed BakhouchLaboratory of Bioorganic Chemistry, Department of Chemistry, Faculty of Sciences, Chouaïb Doukkali University, P.O. Box 24, El Jadida 24000, Morocco.
Mohamed AkhazzaneEngineering Laboratory of Organometallic, Molecular, Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, 30000 Fez, Morocco.
Mohamed BourassUniversité de Bordeaux, CNRS, Bordeaux INP, ISM, UMR 5255, 351 Cours de la Libération, F-33405 Talence, Cédex France.ORCID https://orcid.org/0000-0001-6801-7851
Samir ChtitaLaboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, P.O. Box 7955, Casablanca, Morocco.ORCID https://orcid.org/0000-0003-2344-5101
Yousef A Bin JardanDepartment of Pharmaceutics, College of Pharmacy, King Saud University, 11451 Riyadh, Saudi Arabia.
Maria AugustyniakInstitute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences, University of Silesia in Katowice, Bankowa 9, 40-007 Katowice, Poland.ORCID https://orcid.org/0000-0003-1960-1669
Mohammed BourhiaHigher Institute of Nursing Professions and Technical Health, Laayoune 70000, Morocco.
Mourad A M Aboul-SoudDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
Mohamed El YazidiEngineering Laboratory of Organometallic, Molecular, Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, 30000 Fez, Morocco.
Sidi Mohamed Ben Abdellah University · MAKing Saud University · SAUniversity of Hassan II Casablanca · MACadi Ayyad University · MACentre National de la Recherche Scientifique · FRChouaib Doukkali University · MAInstituts Supérieurs des Professions Infirmières et Techniques de Santé · MAUniversity of Silesia in Katowice · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of new heterocycle hybrids incorporating pyrazole and isoxazoline rings was successfully synthesized, characterized, and evaluated for their antimicrobial responses. The synthesized compounds were obtained utilizing

Identifiers

PMID36570248
PMCPMC9773794
OpenAlexW4312082473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.