ArticleFrontiers in immunology2022
Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- A systematic review of risk factors for vascular dementia using Mendelian randomization: a call for methodologically robust studies to advance knowledge.BMC neurology · 2026Pooled it
- The association between systemic lupus erythematosus and cognitive impairment or dementia: a meta-analysis.Frontiers in immunology · 2026Pooled it
- Integrative multi-omics analysis identifies key ubiquitination regulators in prostate cancer.Translational oncology · 2026Article
- Identification of Biomarkers Associated With Copper Metabolism in Ischemic Stroke Through Bulk RNA Sequencing and Mendelian Randomization Analysis.Cellular and molecular neurobiology · 2026Article
- Integrated stress response genes as novel biomarkers and therapeutic targets in ankylosing spondylitis: a transcriptomic and Mendelian randomization study.Frontiers in immunology · 2026Article
- MAFF as a potential novel protective factor against Parkinson's disease: evidence from Mendelian randomization and single-cell RNA sequencing.Frontiers in aging neuroscience · 2026Article
- Exploring the potential of gut microbiota metabolites in the treatment of endometriosis through network pharmacology and Mendelian randomization.Frontiers in microbiology · 2026Article
- Unveiling novel potential drug targets for lung cancer through Mendelian randomization analysis.Scientific reports · 2025Article
- Causality between rheumatic diseases and iron-deficiency anemia: A 2-sample, 2-step mediation Mendelian randomization investigation.Medicine · 2025Article
- The association between immune cells and acute kidney injury: insights from Mendelian randomization.Renal failure · 2025Article
- Proton pump inhibitors in systemic sclerosis: should we exercise caution? Insights from a large-scale data analysis.Clinical rheumatology · 2025Observational
- Anatomic subtype-specific causal effects of endometriosis on ovarian cancer: a two-sample Mendelian randomization study.Discover oncology · 2025Article
- Potential association between allergic disease and risk of Alzheimer's disease: insight from genetic analysis.BMC neurology · 2025Article
- Identifying key palmitoylation-associated genes in endometriosis through genomic data analysis.BMC women's health · 2025Article
- Association of Sleep Traits, Physical Activity, and Sedentary Leisure Behavior With Female Reproductive Health: A Two-Sample Mendelian Randomization Analysis.International journal of women's health · 2025Article
- Mendelian Randomization Analysis of the Relationship Between Immune-Related Diseases and Alzheimer's Disease.Journal of multidisciplinary healthcare · 2025Article
- Cognitive impairment in individuals with rheumatic diseases: the role of systemic inflammation, immunomodulatory medications, and comorbidities.The Lancet. Rheumatology · 2024Review
- Estimating the prevalence and clinical causality of obstructive sleep apnea in paediatric narcolepsy patients.Sleep & breathing = Schlaf & Atmung · 2024Article
- Exploring genetic association of systemic iron status and risk with incidence of diabetic neuropathy.Diabetology & metabolic syndrome · 2024Article
- Identifying the mediating role of inflammation on the relationship between socioeconomic status and Alzheimer's disease: a Mendelian randomization analysis and mediation analysis.Journal of neurology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: It is well-documented that systemic lupus erythematosus (SLE) is associated with dementia. However, the genetic causality of this association remains unclear. Mendelian randomization (MR) was used to investigate the potential causal relationship between SLE and dementia risk in the current study. Methods: We selected 45 single nucleotide polymorphisms (SNPs) associated with SLE from publicly available genome-wide association studies (GWAS). Summary level statistics were obtained from the dementia GWAS database. MR estimates were performed using the inverse variance weighted (IVW) method, MR-Egger method and weighted median (WM) method. Cochran's Q test, the intercept of MR-Egger, MR-Pleiotropy Residual Sum and Outlier method, leave-one-out analysis and funnel plot were applied for sensitivity analyses. Results: No significant causal association was found between SLE and any type of dementia, including Alzheimer's disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies. These findings were robust across several sensitivity analyses. Conclusion: Overall, our findings do not support a causal association between SLE and dementia risk.
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