Evidence map›Paper›PMID 36569816›Full record

ArticleFunction (Oxford, England)2023

Skeletal Muscle Nuclei in Mice are not Post-mitotic.

Agnieszka K Borowik, Arik Davidyan, Frederick F Peelor, Evelina Voloviceva, Stephen M Doidge, Matthew P Bubak, Christopher B Mobley, John J McCarthy, Esther E Dupont-Versteegden, Benjamin F Miller

Open access · goldAbstract read
In one paragraph

Article in Function (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Mechanisms of Biological Aging with Special Reference to the Skeletal Muscle.Advances in experimental medicine and biology · 2025
    Review
  14. Measurement of Myonuclear Accretion In Vitro and In Vivo.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  15. Article
  16. Review
  17. The impact of cellular senescence on aging skeletal muscle.Frontiers in cell and developmental biology · 2025
    Review
  18. Article
  19. Article
  20. Cell cycle re-entry in the agingbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Agnieszka K BorowikAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA.
Arik DavidyanAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA.ORCID 0000-0001-9003-8528
Frederick F PeelorAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA.
Evelina VolovicevaAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA.ORCID 0000-0002-7313-4822
Stephen M DoidgeAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA.
Matthew P BubakAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA.
Christopher B MobleySchool of Kinesiology, Auburn University, 301 Wire Rd, Auburn, AL 36849, USA.
John J McCarthyCenter for Muscle Biology, University of Kentucky, Lexington, KY 40506, USA.
Esther E Dupont-VersteegdenCenter for Muscle Biology, University of Kentucky, Lexington, KY 40506, USA.
Benjamin F MillerAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA.ORCID 0000-0003-3283-0685
Oklahoma Medical Research Foundation · USUniversity of Kentucky · USAuburn University · US

Funding

GEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6M
DNA turnover in myofibers is an unrecognized mechanism for maintaining skeletal muscle healthR21AR077387 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MILLER, BENJAMIN FRANCIS · 2020 to 2021
$423k
Effect of Satellite Cell Ablation on the Aging DiaphragmR21AG043721 · NIA · UNIVERSITY OF KENTUCKY · PI DUPONT-VERSTEEGDEN, ESTHER E · 2013 to 2014
$413k
Mechanism through which chronically elevated mTOR activity impairs aged muscle recovery after disuse atrophyI01BX005592 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI MILLER, BENJAMIN FRANCIS · 2022 to 2025
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BLRD VA I01 BX005592NIAMS NIH HHS R21 AR077387NIA NIH HHS R21 AG043721NIA NIH HHS T32 AG052363
6 · The paper itself

Abstract

The skeletal muscle research field generally accepts that nuclei in skeletal muscle fibers (ie, myonuclei) are post-mitotic and unable to proliferate. Because our deuterium oxide (D

Indexed as

Muscle Fibers, SkeletalMuscle, SkeletalAnimalsCell NucleusMicePolyestersQuadriceps MusclePolyestersDNA synthesisGrowthMusclemyonucleiStable isotope

Identifiers

PMID36569816
PMCPMC9772608
OpenAlexW4309671656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.