Evidence map›Paper›PMID 36569815›Full record

ReviewTherapeutic advances in infectious disease

Transmission of Group B Streptococcus in late-onset neonatal disease: a narrative review of current evidence.

Francesca Miselli, Ilaria Frabboni, Marianna Di Martino, Isotta Zinani, Martina Buttera, Anna Insalaco, Francesca Stefanelli, Licia Lugli, Alberto Berardi

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  9. Group BAJP reports · 2026
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  14. A murine model of adult gastrointestinal colonization by Group BbioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Francesca MiselliNeonatal Intensive Care Unit, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.ORCID https://orcid.org/0000-0001-5991-8949
Ilaria FrabboniPediatric Post-Graduate School, University of Modena e Reggio Emilia, Modena, Italy.
Marianna Di MartinoPediatric Post-Graduate School, University of Modena e Reggio Emilia, Modena, Italy.
Isotta ZinaniPediatric Post-Graduate School, University of Modena e Reggio Emilia, Modena, Italy.
Martina ButteraPediatric Post-Graduate School, University of Modena e Reggio Emilia, Modena, Italy.
Anna InsalacoPediatric Post-Graduate School, University of Modena e Reggio Emilia, Modena, Italy.
Francesca StefanelliPediatric Post-Graduate School, University of Modena e Reggio Emilia, Modena, Italy.
Licia LugliNeonatal Intensive Care Unit, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.
Alberto BerardiNeonatal Intensive Care Unit, Policlinico University Hospital, 41124 Modena, Italy.ORCID https://orcid.org/0000-0002-3534-7499
University of Modena and Reggio Emilia · ITAzienda Ospedaliero-Universitaria di Modena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group B streptococcus (GBS) late-onset disease (LOD, occurring from 7 through 89 days of life) is an important cause of sepsis and meningitis in infants. The pathogenesis and modes of transmission of LOD to neonates are yet to be elucidated. Established risk factors for the incidence of LOD include maternal GBS colonisation, young maternal age, preterm birth, HIV exposure and African ethnicity. The mucosal colonisation by GBS may be acquired perinatally or in the postpartum period from maternal or other sources. Growing evidence has demonstrated the predominant role of maternal sources in the transmission of LOD. Intrapartum antibiotic prophylaxis (IAP) to prevent early-onset disease reduces neonatal GBS colonisation during delivery; however, a significant proportion of IAP-exposed neonates born to GBS-carrier mothers acquire the pathogen at mucosal sites in the first weeks of life. GBS-infected breast milk, with or without presence of mastitis, is considered a potential vehicle for transmitting GBS. Furthermore, horizontal transmission is possible from nosocomial and other community sources. Although unfrequently reported, nosocomial transmission of GBS in the neonatal intensive care unit is probably less rare than is usually believed. GBS disease can sometime recur and is usually caused by the same GBS serotype that caused the primary infection. This review aims to discuss the dynamics of transmission of GBS in the neonatal LOD.

Indexed as

group B streptococcuslate-onset diseaselate-onset sepsisStreptococcus agalactiaetransmission

Identifiers

PMID36569815
PMCPMC9780763
OpenAlexW4312211673

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.