Evidence map›Paper›PMID 36569607›Full record

ArticleFrontiers in psychiatry2022

Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study.

Fenyang Chen, Luoyu Wang, Zhongxiang Ding

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  3. Current approaches to studying human resting-state function in inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Fenyang ChenThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Luoyu WangDepartment of Radiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhongxiang DingDepartment of Radiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hangzhou First People's Hospital · CNZhejiang Chinese Medical University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mild to moderate depressive disorder has a high risk of progressing to major depressive disorder. Methods: Low-frequency amplitude and degree centrality were calculated to compare 49 patients with mild to moderate depression and 21 matched healthy controls. Correlation analysis was conducted to explore the correlation between the amplitude of low-frequency fluctuation (ALFF) and the degree centrality (DC) of altered brain region and the scores of clinical scale. Receiver operating characteristic (ROC) curves were further analyzed to evaluate the predictive value of above altered ALFF and DC areas as image markers for mild to moderate depression. Results: Compared with healthy controls, patients with mild to moderate depression had lower ALFF values in the left precuneus and posterior cingulate gyrus [voxel Conclusion: Intrinsic abnormality of the brain was mainly located in the precuneus and insular in patients with mild to moderate depression, which provides insight into potential neurological mechanisms.

Indexed as

degree centralitylow-frequency amplitudemild to moderate depressionreceiver operator characteristic curveresting-state functional magnetic resonance imaging

Identifiers

PMID36569607
PMCPMC9768018
OpenAlexW4311709467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.