Evidence map›Paper›PMID 36569591›Full record

ArticleMaterials today. Bio2023

3D-CEUS tracking of injectable chemo-sonodynamic therapy-enabled mop-up of residual renal cell carcinoma after thermal ablation.

Cuixian Li, Piao Zhu, Huijing Xiang, Yunjie Jin, Beilei Lu, Yujia Shen, Wenping Wang, Beijian Huang, Yu Chen

Open access · goldAbstract read
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Cuixian LiDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
Piao ZhuShanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai 200331, PR China.
Huijing XiangMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China.
Yunjie JinDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
Beilei LuDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
Yujia ShenDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
Wenping WangDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
Beijian HuangDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
Yu ChenMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China.
Sun Yat-sen University · CNShanghai University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thermal ablation (TA), as a minimally invasive therapeutic technique, has been extensively used to the treatment of solid tumors, such as renal cell carcinoma (RCC), which, unfortunately, still fails to overcome the high risk of local recurrence and distant metastasis since the incomplete ablation cannot be ignored due to various factors such as the indistinguishable tumor margins and limited ablation zone. Herein, we report the injectable thermosensitive hydrogel by confining curcumin (Cur)-loaded hollow mesoporous organosilica nanoparticles (Cur@HMON@gel) which can locate in tumor site more than half a month and mop up the residual RCC under ultrasound (US) irradiation after transforming from colloidal sol status to elastic gel matrix at physiological temperature. Based on the US-triggered accelerated diffusion of the model chemotherapy drug with multi-pharmacologic functions, the sustained and controlled release of Cur has been demonstrated

Indexed as

Chitosan, CSContrast-enhanced ultrasoundControlled drug releaseCurcuminCurcumin (Cur)-loaded hollow mesoporous organosilica nanoparticles, Cur@HMON@gelHollow mesoporous organosilica nanoparticle, HMONReactive oxygen species, ROSRenal cell carcinomaRenal cell carcinoma, RCCSonodynamic therapySonodynamic therapy, SDTThermal ablationThermal ablation, TAThree-dimensional contrast-enhanced ultrasound, 3D-CEUSUltrasound, US

Identifiers

PMID36569591
PMCPMC9771734
OpenAlexW4310676747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.