Evidence map›Paper›PMID 36569505›Full record

ArticleBJUI compass2023

Combining PSA and PET features to select candidates for salvage lymph node dissection in recurrent prostate cancer.

Carlo A Bravi, Axel Heidenreich, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Armando Stabile, Vito Cucchiara, Daniar Osmonov, Klaus-Peter Juenemann and 19 more

Open access · goldAbstract read
In one paragraph

Article in BJUI compass, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 15 institutions in 7 countries.

Carlo A BraviDivision of Oncology/Unit of Urology, URI IRCCS Ospedale San Raffaele Milan Italy.ORCID https://orcid.org/0000-0002-6412-9546
Axel HeidenreichDepartment of Urology University of Cologne Cologne Germany.ORCID https://orcid.org/0000-0002-2511-3664
Nicola FossatiDivision of Oncology/Unit of Urology, URI IRCCS Ospedale San Raffaele Milan Italy.
Giorgio GandagliaDivision of Oncology/Unit of Urology, URI IRCCS Ospedale San Raffaele Milan Italy.ORCID https://orcid.org/0000-0002-5052-721X
Nazareno SuardiDepartment of Urology, Policlinico San Martino Hospital University of Genova Genoa Italy.
Elio MazzoneDivision of Oncology/Unit of Urology, URI IRCCS Ospedale San Raffaele Milan Italy.ORCID https://orcid.org/0000-0003-1932-1800
Armando StabileDivision of Oncology/Unit of Urology, URI IRCCS Ospedale San Raffaele Milan Italy.
Vito CucchiaraDivision of Oncology/Unit of Urology, URI IRCCS Ospedale San Raffaele Milan Italy.
Daniar OsmonovDepartment of Urology and Pediatric Urology, Campus Kiel University Hospital Schleswig Holstein Kiel Germany.
Klaus-Peter JuenemannDepartment of Urology and Pediatric Urology, Campus Kiel University Hospital Schleswig Holstein Kiel Germany.
R Jeffrey KarnesDepartment of Urology Mayo Clinic Rochester Minnesota USA.ORCID https://orcid.org/0000-0003-2339-5925
Alexander KretschmerDepartment of Urology Ludwig-Maximilians-University Munich Germany.ORCID https://orcid.org/0000-0002-6511-4354
Alexander BuchnerDepartment of Urology Ludwig-Maximilians-University Munich Germany.
Christian StiefDepartment of Urology Ludwig-Maximilians-University Munich Germany.
Andreas HiesterUniversitätsklinikum des Saarlandes Homburg Germany.
Peter AlbersDepartment of Urology, Medical Faculty Heinrich-Heine-University Düsseldorf Germany.
Gaëtan DevosDepartment of Urology University Hospitals Leuven Leuven Belgium.ORCID https://orcid.org/0000-0002-6772-915X
Steven JoniauDepartment of Urology University Hospitals Leuven Leuven Belgium.
Hendrik Van PoppelDepartment of Urology University Hospitals Leuven Leuven Belgium.
Bernhard GrubmüllerDepartment of Urology Medical University of Vienna Vienna Austria.
Shahrokh ShariatDepartment of Urology Medical University of Vienna Vienna Austria.
Derya TilkiDepartment of Urology University Hospital Hamburg-Eppendorf Hamburg Germany.
Markus GraefenDepartment of Urology University Hospital Hamburg-Eppendorf Hamburg Germany.
Inderbir S GillUSC Institute of Urology University of Southern California Los Angeles California USA.
Alexander MottrieDepartment of Urology OLV Ziekenhuis Aalst Aalst Belgium.
Pierre I KarakiewiczCancer Prognostics and Health Outcomes Unit University of Montreal Health Centre Montreal Quebec Canada.
Francesco MontorsiDivision of Oncology/Unit of Urology, URI IRCCS Ospedale San Raffaele Milan Italy.ORCID https://orcid.org/0000-0002-7267-4181
Alberto BrigantiDivision of Oncology/Unit of Urology, URI IRCCS Ospedale San Raffaele Milan Italy.
David PfisterDepartment of Urology University of Cologne Cologne Germany.ORCID https://orcid.org/0000-0003-3925-9653
IRCCS Ospedale San Raffaele · ITLudwig-Maximilians-Universität München · DEUniversitair Ziekenhuis Leuven · BEChristian-Albrechts-Universität zu Kiel · DEOnze Lieve Vrouwziekenhuis Hospital · BEUniversität Hamburg · DEUniversity of Cologne · DEHeinrich Heine University Düsseldorf · DEMayo Clinic · USMcGill University Health Centre · CAMedical University of Vienna · ATOspedale Policlinico San Martino · ITSechenov University · RUUniversitätsklinikum des Saarlandes · DEUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the relationship between pre-operative PSA value, Patients and methods: The study included 164 patients diagnosed with ≤2 pelvic lymph-node recurrence(s) of PCa documented on Results: Median [interquartile range (IQR)] PSA at sLND was 1.1 (0.6, 2.0) ng/ml, and 131 (80%) patients had one positive spot at PET scan. All patients received pelvic sLND, whereas 91 (55%) men received also retroperitoneal dissection. Median (IQR) number of node removed was 15 (6, 28). The rate of positive pathology increased as a function of pre-operative PSA value, with highest rates for patients with pre-operative PSA > 1.5 ng/ml (pelvic-only sLNDs: 84%; pelvic + retroperitoneal sLNDs: 90%). After sLND, PSA ≤ 0.3 ng/ml was detected in 67 (41%) men. On multivariable analyses, pre-operative PSA was associated with PSA response ( Conclusions: In case of PET-detected nodal recurrences amenable to sLND, salvage surgery was associated with the highest short-term oncologic outcomes when performed in men with PSA ≥ 1 ng/ml. Awaiting confirmatory data from prospective trials, these findings may help physicians to optimize the timing for

Indexed as

androgen deprivation therapymetastasis‐directed therapyneoplasm recurrenceprostate cancerPSMA PET scansalvage lymph node dissection

Identifiers

PMID36569505
PMCPMC9766859
OpenAlexW4289943577

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.