Trial reportWorld journal of gastroenterology2022
Diagnostic evaluation of endoscopic ultrasonography with submucosal saline injection for differentiating between T1a and T1b early gastric cancer.
Trial report in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Combined multidetector computed tomography and gastrointestinal endoscopy for gastric cancer screening, preoperative staging, and lymph node metastasis detection.World journal of gastrointestinal oncology · 2026Article
- Submucosal saline injection-assisted endoscopic ultrasonography for accurate layer identification of a rectal subepithelial lesion.Endoscopy · 2025Article
- Enhanced diagnostic accuracy of SINE-EUS compared to standard EUS in early colorectal cancer: a self-controlled study.International journal of colorectal disease · 2025Article
- Endoscopic ultrasound with submucosal saline injection improves the accuracy of T1a and T1b staging in superficial esophageal squamous cell carcinoma.Frontiers in medicine · 2025Article
- Survival and Treatment Outcomes in Gastric Cancer Patients with Brain Metastases: A Systematic Review and Meta-Analysis.Cancers · 2024Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic ultrasonography (EUS) has become a reliable method for predicting the invasion depth of early gastric cancer (EGC). However, diagnostic accuracy of EUS is affected by several factors. In particular, it is difficult to differentiate between T1a and T1b EGC through EUS.
aimTo confirm whether submucosal saline injection (SSI) could improve the accuracy of EUS in distinguishing T1a and T1b lesions in EGC.
methodsTwenty-four patients with EGC were examined by EUS and subsequently by SSI combined EUS to compare the degree of tumor invasion. Then, they underwent endoscopic or surgical resection within 7 d. The diagnostic accuracy of EUS and SSI combined EUS was evaluated based on the final pathological findings postoperatively. Saline injected into the submucosa acted as an echoic contrast enhancing agent and had the effect of distinguishing the mucosal and submucosal layers clearly.
resultsOf total 24 patients, 23 were diagnosed with EGC (T1 cancer: 13 as T1a, and 10 as T1b). Standard EUS identified 6 of 13 T1a cancer patients and 3 of 10 T1b cancer patients. Whereas, EUS-SSI identified 12 of 13 T1a cancer patients and 6 of 10 T1b cancer patients. In this study, SSI combined EUS was more accurate than EUS alone in diagnosing T1a and T1b lesions of EGC (75.0% and 37.5%, respectively).
conclusionSSI improved the diagnostic accuracy of EUS in distinguishing between the T1a and T1b stages in EGC.
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