Evidence map›Paper›PMID 36568982›Full record

ArticleFrontiers in cell and developmental biology2022

Loss of ARHGAP15 affects the directional control of migrating interneurons in the embryonic cortex and increases susceptibility to epilepsy.

Carla Liaci, Mattia Camera, Valentina Zamboni, Gabriella Sarò, Alessandra Ammoni, Elena Parmigiani, Luisa Ponzoni, Enis Hidisoglu, Giuseppe Chiantia, Andrea Marcantoni and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. The genetic architecture of fibromyalgia across 2.5 million individuals.medRxiv : the preprint server for health sciences · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Carla LiaciDepartment of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.
Mattia CameraDepartment of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.
Valentina ZamboniDepartment of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.
Gabriella SaròDepartment of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.
Alessandra AmmoniDepartment of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.
Elena ParmigianiNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy.
Luisa PonzoniNeuroscience Institute, Consiglio Nazionale Ricerche, Milan, Italy.
Enis HidisogluDepartment of Drug Science, NIS Center, University of Turin, Turin, Italy.
Giuseppe ChiantiaDepartment of Neuroscience and National Institute of Neuroscience, University of Turin, Turin, Italy.
Andrea MarcantoniDepartment of Drug Science, NIS Center, University of Turin, Turin, Italy.
Maurizio GiustettoDepartment of Neuroscience and National Institute of Neuroscience, University of Turin, Turin, Italy.
Giulia TomagraDepartment of Drug Science, NIS Center, University of Turin, Turin, Italy.
Valentina CarabelliDepartment of Drug Science, NIS Center, University of Turin, Turin, Italy.
Federico TorelliInstitute for Physiology I, Medical Faculty, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Mariaelvina SalaNeuroscience Institute, Consiglio Nazionale Ricerche, Milan, Italy.
Yuchio YanagawaDepartment of Genetic Behavioral Neuroscience, Gunma University, Maebashi, Japan.
Kunihiko ObataRIKEN Brain Science Institute, Wako, Saitama, Japan.
Emilio HirschDepartment of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.
Giorgio R MerloDepartment of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.
University of Turin · ITNeuroscience Institute · ITGunma University · JPRIKEN Center for Brain Science · JPUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GTPases of the Rho family are components of signaling pathways linking extracellular signals to the control of cytoskeleton dynamics. Among these, RAC1 plays key roles during brain development, ranging from neuronal migration to neuritogenesis, synaptogenesis, and plasticity. RAC1 activity is positively and negatively controlled by guanine nucleotide exchange factors (GEFs), guanosine nucleotide dissociation inhibitors (GDIs), and GTPase-activating proteins (GAPs), but the specific role of each regulator

Indexed as

ARHGAP15epilepsyinhibitory neuronsneuronal migrationRAC1Rho GTPases

Identifiers

PMID36568982
PMCPMC9774038
OpenAlexW4311872419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.