Evidence map›Paper›PMID 36568777›Full record

ArticleFrontiers in public health2022

Time above range for predicting the development of type 2 diabetes.

Alejandra Marco, Marcos Pazos-Couselo, Jesús Moreno-Fernandez, Ana Díez-Fernández, Manuela Alonso-Sampedro, Carmen Fernández-Merino, Arturo Gonzalez-Quintela, Francisco Gude

Open access · goldAbstract read
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Observational
  2. Article
  3. The Expanding Role of Continuous Glucose Monitoring in the Management and Prevention of Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Review
  4. Article
  5. Article
  6. Evaluation of Asymptomatic Fasting Hypoglycemia in Outpatients Without Diabetes.Journal of the American Board of Family Medicine : JABFM · 2025
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Alejandra MarcoPrimary Care Center, Santiago de Compostela, Spain.
Marcos Pazos-CouseloResearch Methods (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Jesús Moreno-FernandezEndocrinology and Nutrition Service, Ciudad Real General University Hospital, Ciudad Real, Spain.
Ana Díez-FernándezFacultad de Enfermería de Cuenca, Universidad de Castilla-La Mancha, Cuenca, Spain.
Manuela Alonso-SampedroResearch Methods (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Carmen Fernández-MerinoResearch Methods (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Arturo Gonzalez-QuintelaResearch Methods (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Francisco GudeResearch Methods (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Instituto de Investigación Sanitaria de Santiago · ESComplejo Hospitalario Universitario de Santiago · ESFundación Andrés Marcio · ESHospital General Universitario de Ciudad Real · ESUniversity of Castilla-La Mancha · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To investigate the prognostic value of time range metrics, as measured by continuous glucose monitoring, with respect to the development of type 2 diabetes (T2D). Research design and methods: A total of 499 persons without diabetes from the general population were followed-up for 5 years. Time range metrics were measured at the start and medical records were checked over the period study. Results: Twenty-two subjects (8.3 per 1,000 person-years) developed T2D. After adjusting for age, gender, family history of diabetes, body mass index and glycated hemoglobin concentration, multivariate analysis revealed 'time above range' (TAR, i.e., with a plasma glucose concentration of >140 mg/dL) to be significantly associated with a greater risk (OR = 1.06, CI 1.01-1.11) of developing diabetes (AUC = 0.94, Brier = 0.035). Conclusions: Time above range provides additional information to that offered by glycated hemoglobin to identify patients at a higher risk of developing type 2 diabetes in a population-based study.

Indexed as

Diabetes Mellitus, Type 2Blood GlucoseBlood Glucose Self-MonitoringGlycated HemoglobinHumansPrognosisBlood GlucoseGlycated Hemoglobincontinuous glucose monitor systemdiabetes prediction and preventiondiabetes riskprimary caretype 2 diabetes

Identifiers

PMID36568777
PMCPMC9772988
OpenAlexW4311858099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.