Evidence map›Paper›PMID 36568656›Full record

ArticleHeliyon2022

Orai1 overexpression improves sepsis-induced T-lymphocyte immunosuppression and acute organ dysfunction in mice.

Longwang Chen, Heliang Ke, Yaolu Zhang, Pinpin Jin, Xinyong Liu, Guangliang Hong, Guangju Zhao, Zhongqiu Lu, Bin Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy.Frontiers in cellular and infection microbiology · 2025
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Longwang ChenEmergency Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Heliang KeEmergency Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Yaolu ZhangEmergency Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Pinpin JinEmergency Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Xinyong LiuEmergency Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Guangliang HongEmergency Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Guangju ZhaoEmergency Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Zhongqiu LuEmergency Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Bin WuEmergency Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
First Affiliated Hospital of Wenzhou Medical University · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune paralysis induced by sepsis, especially dysfunction of CD4

Indexed as

ImmunosuppressionNFATOrai1SepsisTh17Treg

Identifiers

PMID36568656
PMCPMC9768300
OpenAlexW4310735639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.