Evidence map›Paper›PMID 36568284›Full record

ArticleVascular health and risk management2022

Rapid Rise in Cardio-Ankle Vascular Index as a Predictor of Impending Cardiovascular Events -Smooth Muscle Cell Contraction Hypothesis for Plaque Rupture.

Kazuhiro Shimizu, Mao Takahashi, Shuji Sato, Atsuhito Saiki, Daiji Nagayama, Takashi Hitsumoto, Akira Takahara, Kohji Shirai

Open access · goldAbstract read
In one paragraph

Article in Vascular health and risk management, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kazuhiro ShimizuDepartment of Internal Medicine, Toho University Sakura Medical Center, Sakura, Chiba, Japan.ORCID 0000-0001-9896-0939
Mao TakahashiDepartment of Internal Medicine, Toho University Sakura Medical Center, Sakura, Chiba, Japan.ORCID 0000-0003-2808-2020
Shuji SatoDepartment of Internal Medicine, Toho University Sakura Medical Center, Sakura, Chiba, Japan.ORCID 0000-0002-6386-8670
Atsuhito SaikiDepartment of Internal Medicine, Toho University Sakura Medical Center, Sakura, Chiba, Japan.
Daiji NagayamaDepartment of Internal Medicine, Toho University Sakura Medical Center, Sakura, Chiba, Japan.ORCID 0000-0001-6119-8012
Takashi HitsumotoHitsumoto Medical Clinic, Shimonoseki, Yamaguchi, Japan.
Akira TakaharaDepartment of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.ORCID 0000-0003-2190-2444
Kohji ShiraiDepartment of Internal Medicine, Toho University Sakura Medical Center, Sakura, Chiba, Japan.
Toho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Predictive factors for vascular events have not been established. The vasculature of the atheroma is supplied by penetration of the vasa vasorum through the smooth muscle cell layer from the adventitia. Smooth muscle cell contraction induces compression of the vasa vasorum, resulting in ischemia in intimal atheromatous lesions. Cardio-ankle vascular index (CAVI) has become known as an index of arterial stiffness of the arterial tree from the origin of the aorta to the ankle. CAVI reflects the progress of arteriosclerosis, and a rapid rise in CAVI indicates arterial smooth muscle cell contraction. We hypothesized that rapidly increased arterial stiffness evaluated by CAVI may be a predictor of impending cardiovascular events.

Indexed as

Cardiovascular DiseasesPlaque, AtheroscleroticVascular StiffnessAnkleArteriesCardio Ankle Vascular IndexHumansarterial stiffnessCAVIplaque rupturestress

Identifiers

PMID36568284
PMCPMC9784386
OpenAlexW4312049319

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.