ArticleFrontiers in oncology2022
Risk factors of cervical lymph node metastasis in multifocal papillary thyroid cancer.
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Transoral endoscopic thyroidectomy submental vestibular approach for early-stage papillary thyroid carcinoma: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2024Pooled it
- Clinicopathological Predictors of Contralateral Central Lymph Node Metastasis in Patients With Unifocal Papillary Thyroid Carcinoma.Head & neck · 2026Article
- Delphian lymph node metastasis as a marker of extensive nodal involvement in papillary thyroid cancer.BMC surgery · 2026Article
- Prediction of contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma based on radiomics.Scientific reports · 2025Article
- Mandibular metastasis of papillary thyroid carcinoma: a case report and systematic literature review.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025Review
- Assessing the Role of Inflammatory Markers in Predicting Central Lymph Node Metastasis in Papillary Thyroid Carcinoma.Iranian journal of otorhinolaryngology · 2025Article
- Risk factors for cervical lymph node metastasis of papillary thyroid cancer in elderly patients aged 65 and older.Frontiers in endocrinology · 2024Article
- Optimal surgical population for cervical lymph node dissection in PTC.Frontiers in oncology · 2024Article
- Radiomics features from whole thyroid gland tissue for prediction of cervical lymph node metastasis in the patients with papillary thyroid carcinoma.Journal of cancer research and clinical oncology · 2023Article
- Role of prophylactic central neck lymph node dissection for papillary thyroid carcinoma in the era of de-escalation.World journal of clinical oncology · 2023Review
- Comment on "Surgical Outcomes in Patients With Low-Risk Papillary Thyroid Microcarcinoma from MAeSTro Study: Immediate Operation Versus Delayed Operation Following Active Surveillance A Multicenter Prospective Cohort Study".Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Identifying risk variables for cervical lymph node metastases in multifocality papillary thyroid cancer (MPTC) could assist surgeons in determining whether cervical lymph node dissection would be an appropriate surgical option. Methods: A retrospective cohort of 2006 patients with papillary thyroid cancer were selected. MPTC (N = 460) was defined as the presence of two or more foci of PTC. The risk factors for central lymph node metastasis (CLNM) and lateral lymph node metastasis (LLNM) in MPTC were investigated by univariate and multivariate analyses, including the following items: age at diagnosis, gender, Hashimoto's thyroiditis, extrathyroidal extension (ETE), maximal axial diameter (MAD) and the sum of axial diameters (SAD) of tumor. In addition, CLNM was used to evaluate LLNM. Results: The incidence of CLNM and LLNM was 44.57% and 17.17%, respectively. The multivariate analysis demonstrated that gender, extrathyroidal extension (ETE), age, maximal axial diameter (MAD), and the sum of axial diameters (SAD) were related to increased risk for CLNM in MPTC ( Conclusions: MPTC patients who have risk factors for CLNM were advised to perform prophylactic central lymph node dissection (CLND). Additionally, the presence of risk factors for LLNM should be individually evaluated and analyzed for the necessity of lateral lymph node dissection.
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