ArticleFrontiers in oncology2022
Trends of sphincter-preserving surgeries for low lying rectal cancer: A 20-year experience in China.
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Optimal interventions for low anterior resection syndrome: Bayesian network meta-analysis of randomized controlled trials.Techniques in coloproctology · 2025Pooled it
- Effect of a Mobile Health-Based Remote Interaction Management Intervention on the Quality of Life and Self-Management Behavior of Patients With Low Anterior Resection Syndrome: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Evolution of treatment patterns and survival outcomes in non-metastatic rectal cancer: a 15-year real-world single-center analysis.BMC cancer · 2026Article
- Prevalence of and risk factors for low anterior resection syndrome based on the international consensus definition: a multicenter cross-sectional observational study.Surgery today · 2026Observational
- Development and validation of web-based prediction models for major low anterior resection syndrome at 3 and 6 months after sphincter-preserving surgery in patients with rectal cancer.International journal of colorectal disease · 2026Article
- Pharmacological Therapies for Bowel Dysfunction After Colorectal Cancer Surgery: A Systematic Review.Advanced pharmaceutical bulletin · 2026Review
- Low anterior resection syndrome after sphincter-preserving surgery for rectal cancer: predictive factors and impact on perceived functional satisfaction.Discover oncology · 2026Article
- Ileostoma as a promising tool in pathophysiological study and clinical intervention: a review from bench to beside.Frontiers in immunology · 2026Review
- Double-tube end ileostomy: an alternative to classical defunctioning stoma in rectal surgery.Techniques in coloproctology · 2025Article
- Self-efficacy and symptom distress in sphincter-preserving rectal cancer patients: the mediating role of intestinal symptoms self-management.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Predictive model for sphincter preservation in lower rectal cancer.World journal of clinical oncology · 2025Article
- Long-term efficacy and short-term outcomes of intersphincteric resectionWorld journal of gastroenterology · 2025Article
- Sphincter-preserving surgical techniques in low rectal cancer management: A systematic review of contemporary evidence.World journal of gastrointestinal surgery · 2025Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Over the last 2 decades, patients with low rectal cancer have had better outcomes from improvements in surgical techniques in sphincter preservation. We aimed to quantify the trends in sphincter-preserving surgeries for low rectal cancer over 20 years in a top tertiary hospital in China. Methods: Between 1999 and 2021, a cohort of patients with primary malignant rectal tumor ≤5cm from the anal verge and who received elective surgeries at Changhai Hospital, Shanghai, China, was identified. Data were extracted from electronic medical records. A Joinpoint Regression Model was used to analyze trends in surgical procedures by average annual percentage change (AAPC). Adjusted Cox proportional hazards regression model was used to assess overall survival. Results: Among a total of 4,172 patients during the study period, 3,111 (74.6%) underwent a sphincter-preserving surgery and 1,061 (25.4%) received APR. Sphincter-preserving surgery increased 3.6% per year (95%CI, 2.3-4.9). Low anterior resection was the most performed procedure (86.3%) and maintained a steady trend, while intersphincteric resection increased 49.4% annually (95%CI, 19.5-86.7) after initiation. Laparoscopic techniques increased 15.1% per year (95%CI, 8.4-43.4) after initiation. Sphincter-preserving surgery increased annually for tumors ≤2cm, 2-≤3cm and 3-≤4cm from the anal verge (AAPC 7.1, 4.5-9.8; 4.7, 3.1-6.3; 2.7, 1.7-3.6, respectively). Furthermore, patients with sphincter-preserving surgery had a better overall survival than abdominoperineal resection (APR) patients (adjusted HR 0.78, 95% CI, 0.65-0.93, p=.01). Conclusions: Utilization of sphincter-preserving surgeries increased significantly over the last 20 years. Patients with low rectal cancer who underwent sphincter preservation had better survival than similar patients who underwent APR.
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