Evidence map›Paper›PMID 36567843›Full record

ArticleJournal of medicine and life2022

Combined central and peripheral demyelination: a case report.

Elena Costru-Tasnic, Elena Manole, Vitalie Lisnic

Abstract readCase Reports
In one paragraph

Article in Journal of medicine and life, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elena Costru-TasnicNeurology Department No. 1, Nicolae Testemițanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
Elena ManoleNeurology Department No. 1, Nicolae Testemițanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
Vitalie LisnicNeurology Department No. 1, Nicolae Testemițanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overlapping central nervous system (CNS) and peripheral nervous system (PNS) demyelination is a rare clinical entity, more frequently seen in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and multiple sclerosis (MS). This case report showcases a patient with atypical CIDP and CNS demyelination lesions. Demographic data, disease course, treatment responsiveness, neurological examination, laboratory tests, nerve conduction studies (NCS), and brain and spinal cord MRI were registered. The case highlights the difficulty of diagnosis establishment and treatment selection, given the atypical course of the disease and limited answers to the indicated therapies. The data from our report suggest that specific and widely available immunological targets are necessary for diagnosing combined central and peripheral demyelination cases appropriately. The association of different immunotherapeutic agents may be necessary to induce and maintain disease remission.

Indexed as

Multiple SclerosisPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingBrainCentral Nervous SystemHumansPeripheral Nervous SystemAIDP – acute inflammatory demyelinating polyneuropathyCCPD – combined central and peripheral demyelinationchronic inflammatory demyelinating polyneuropathyCIDP – chronic inflammatory demyelinating polyneuropathyCNS – central nervous systemcombined central and peripheral demyelinationCSF – cerebrospinal fluidimmunotherapyIVIg – intravenous immunoglobulinLE – lower extremityMRC – Medical Research CouncilMRI – magnetic resonance imagingMS – multiple sclerosismultiple sclerosisNCS – nerve conduction studiesPLEX – plasma exchangePNS – peripheral nervous

Identifiers

PMID36567843
PMCPMC9762372

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.