Evidence map›Paper›PMID 36567832›Full record

ReviewJournal of medicine and life2022

Relevant biomarkers of kidney allograft rejection.

Luminița Loga, Lucia Dican, Horea Vladi Matei, Ion Mărunțelu, Ileana Constantinescu

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of medicine and life, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Orchestrating the Impact of KIR/HLA Interactions on Kidney Transplant.International journal of molecular sciences · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Luminița LogaClinical Institute of Urology and Renal Transplant, Cluj-Napoca, Romania.
Lucia DicanClinical Institute of Urology and Renal Transplant, Cluj-Napoca, Romania.
Horea Vladi MateiDepartment of Cell and Molecular Biology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Ion MărunțeluImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Ileana ConstantinescuImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Iuliu Hațieganu University of Medicine and Pharmacy · ROInstitutul Clinic Fundeni · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review focuses on the new relevant biomarkers proposed for the diagnosis of different types of allograft rejections. The immune response against the transplanted tissues can lead to rejection. Kidney allograft rejection occurs when the recipient component's immune system reacts against the donor's cells. MicroRNAs, dd-cf DNA, CD103 markers, CXCR3 chemokine receptor, IP-10, KIR genes, HLA antibodies, the perforin and granzyme B molecules - the constant assessment of all these parameters could prevent acute rejection episodes and kidney injuries. In this way, both immune response and tissue destruction biomarkers are essential for the long-term survival of kidney-transplanted patients. They also contribute to personalizing treatments, precisely personalized immunosuppressive regiments.

Indexed as

Graft RejectionHLA AntigensAllograftsBiomarkersHumansKidneyBiomarkersHLA AntigensbiomarkersCDC – complement-dependent lymphocytotoxicitydd-cf DNA – Donor-derived cell-free DNADNA – deoxyribonucleic acidHLAHLA – Human leukocyte antigenskidney transplantLSA – Luminex Single AntigenmiRNA – micro-RNAsNK – Natural killerPRA – panel reactive antibodyrejectionsensitizationTGF-β – transforming growth factor-beta

Identifiers

PMID36567832
PMCPMC9762359
OpenAlexW4313424355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.