Evidence map›Paper›PMID 36567787›Full record

ArticleCritical care explorations2022

Bioenergetic Crisis in ICU-Acquired Weakness Gene Signatures Was Associated With Sepsis-Related Mortality: A Brief Report.

Seibi Kobara, Milad G Rad, Jocelyn R Grunwell, Craig M Coopersmith, Rishikesan Kamaleswaran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Seibi KobaraDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Milad G RadDepartment of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA.
Jocelyn R GrunwellDepartment of Pediatrics, Division of Critical Care, Emory University School of Medicine, Atlanta, GA.
Craig M CoopersmithDepartment of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA.
Rishikesan KamaleswaranDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA.
Emory University · USChildren's Healthcare of Atlanta · USGeorgia Institute of Technology · US

Funding

Mechanisms of Intestinal Integrity in Sepsis and ShockR01GM072808 · NIGMS · WASHINGTON UNIVERSITY · PI COOPERSMITH, CRAIG M · 2005 to 2021
$5.1M
The Impact of Cancer on the Pathophysiology of SepsisR01GM104323 · NIGMS · EMORY UNIVERSITY · PI COOPERSMITH, CRAIG M, FORD, MANDY L · 2013 to 2021
$2.4M
NIGMS NIH HHS R01 GM072808NIGMS NIH HHS R01 GM104323
6 · The paper itself

Abstract

To investigate the relationship between ICU-acquired weakness (ICUAW) signatures and sepsis-related mortality using gene expression from the blood within 24 hours of sepsis onset.

designObservational study using differential gene expression analysis.

settingPublicly available gene expression profile GSE54514, single-center medical and surgical ICU. PATIENTS: Patients with primary bacteremia- and respiratory-triggered sepsis including 8 nonsurvivors and 13 survivors who were 18 years old and older and admitted to ICU. MEASUREMENTS AND MAIN

resultsAmong validated 526 ICUAW gene signatures, differential gene expression analysis controlling for age identified 38 significantly expressed genes between nonsurvivors and survivors. Functional enrichment analysis of differentially expressed ICUAW genes identified impaired cadherin binding, sarcomere formation, and energy metabolism among nonsurvivors.

conclusionsOur findings demonstrated a biological association between sepsis-related mortality and ICUAW signatures in the early phase of sepsis. Defects in energy metabolism and muscle fiber formation were associated with sepsis-related mortality.

Indexed as

immunosuppression, and catabolism syndromeintensive care unit-acquired weaknessmortalitypersistent inflammationpost-intensive care syndromesepsis

Identifiers

PMID36567787
PMCPMC9760600
OpenAlexW4312211664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.